Pulmonary Hypertension in Left Heart Disease in Adults
Official title: Pulmonary Hypertension in Left Heart Disease
Funded at Mayo Clinic Rochester · NIH-11324637 · Data updated 2026-11-12
A Mayo Clinic-led study is exploring why high blood pressure in the lungs happens with left heart disease in adults and how to tailor treatments based on lung vessel differences.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project start | June 1, 2023 |
| Project end | May 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $773,826 |
| NIH project number | 5R01HL162828-04 |
| Project ID | NIH-11324637 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with left heart disease who develop pulmonary hypertension, followed at participating centers, and who can undergo advanced hemodynamic testing and related assessments.
✕Less likely to help
Patients without left heart disease–related pulmonary hypertension or those unable to undergo the proposed hemodynamic phenotyping may not benefit.
What this research studies
This project looks at adults with left heart disease who develop pulmonary hypertension and may experience right heart strain. Researchers will use new ways to classify the lung blood vessels and distinguish where disease manifests (pulmonary arteries vs veins) to guide therapy choices. They will study human patients and relevant models to understand the biology behind treatment responses and identify mismatches that lead to harmful or ineffective results. The goal is to create a more precise approach so future treatments can better help people with PH linked to left heart disease.
Why it matters
Potential benefit: If successful, the work could lead to more personalized and safer treatments for PH-LHD, potentially reducing symptoms and improving outcomes.
How similar studies have gone: Prior work in PH has shown variable responses to therapies, underscoring the need for phenotype-specific strategies in PH-LHD.
Where this research is happening
-
Mayo Clinic Rochester
Rochester, United States Active
Researchers
- Principal investigator: Redfield, Margaret M — Mayo Clinic Rochester
- Study coordinator: Redfield, Margaret M
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.