Understanding pulmonary hypertension caused by left heart disease
Official title: Pulmonary Hypertension in Left Heart Disease
Funded at Mayo Clinic Rochester · NIH-11111177 · Data updated 2026-11-12
This study is looking at how problems with the left side of the heart can cause high blood pressure in the lungs and issues with the right side of the heart, and it aims to find better ways to treat patients by understanding their unique conditions and the biological processes involved.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project start | June 1, 2023 |
| Project end | May 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $789,618 |
| NIH project number | 5R01HL162828-03 |
| Project ID | NIH-11111177 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults diagnosed with left heart disease who are experiencing pulmonary hypertension.
✕Less likely to help
Patients with pulmonary hypertension not related to left heart disease may not benefit from this research.
What this research studies
This research investigates how left heart disease leads to pulmonary hypertension and right ventricular failure. It aims to identify the specific mechanisms and classifications of pulmonary vascular disease associated with this condition. By using advanced hemodynamic assessments, the study will categorize patients based on their unique vascular responses, which could help tailor more effective treatments. The research also seeks to explore the biological pathways involved in pulmonary vascular disease to improve therapeutic strategies.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for patients suffering from pulmonary hypertension due to left heart disease.
How similar studies have gone: Previous research on pulmonary hypertension has shown promising results, but this approach to specifically address left heart disease is relatively novel.
Where this research is happening
-
Mayo Clinic Rochester
Rochester, United States Active
Researchers
- Principal investigator: Redfield, Margaret M — Mayo Clinic Rochester
- Study coordinator: Redfield, Margaret M
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Pulmonary Hypertension in Left Heart Disease in Adults
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.