Promoting follow-up after abnormal colorectal cancer screening in safety-net systems
Official title: PROACT: Promoting Follow-up of Abnormal Colorectal Cancer Screening Tests through Multilevel Interventions
Funded at Fred Hutchinson Cancer Center · NIH-11381170 · Data updated 2026-11-12
A multilevel program will help people in safety-net hospitals complete follow-up colonoscopy after an abnormal stool test.
Quick facts
| Grant type | R37 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Fred Hutchinson Cancer Center NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | August 1, 2025 |
| Project end | July 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $601,829 |
| NIH project number | 5R37CA295618-02 |
| Project ID | NIH-11381170 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults who receive care in safety-net healthcare systems and have an abnormal FIT result indicating potential colorectal cancer
✕Less likely to help
Patients not in safety-net systems or with normal follow-up plans may not benefit from this intervention.
What this research studies
If you have a higher risk due to a safety-net setting, this project tests an intervention designed to make it easier to get a colonoscopy after an abnormal screening test. It looks at barriers at multiple levels of care, such as transportation or fears about the procedure, and compares the multilevel approach to usual care. The study is conducted within safety-net systems to see how it works in real-world, resource-limited clinics. Findings will guide how to improve timely follow-up and reduce late-stage colorectal cancer. Participation would involve standard clinical follow-up processes and data collection in these settings.
Why it matters
Potential benefit: If successful, this program could shorten the time to follow-up and reduce late-stage cancer and deaths among patients in safety-net systems.
How similar studies have gone: Previous work shows that targeted, multilevel approaches can improve follow-up rates in complex care settings, though results vary by context.
Where this research is happening
-
Fred Hutchinson Cancer Center
Seattle, United States Active
Researchers
- Principal investigator: Issaka, Rachel B. — Fred Hutchinson Cancer Center
- Study coordinator: Issaka, Rachel B.
Related research
Other NIH-funded projects on the same topics.
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Improving colorectal cancer screening and follow-up care.
This study is working to help more people get screened for colorectal cancer and receive the follow-up care they need, especially those who haven't been screened much before, so that everyone can have better access to important health checks and improve their overall health.
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Making colorectal cancer screening easier and more likely to happen
This project uses default options, simpler choices, and direct outreach to help average-risk adults who are overdue complete colorectal cancer screening with colonoscopy or stool tests.
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AI/AN Tailoring of a Home-Based Cervical and Colorectal Cancer Screening Program
A tailored, home-based cancer screening program helps AI/AN adults screen for cervical and colorectal cancer from home using self-collection tests and culturally aligned education.
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Bringing colorectal cancer screening to adults 45–54 who haven’t been screened
A grant to help low-income adults aged 45–54 start colorectal cancer screening through the Boston area’s community health centers.
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Increasing follow-up colonoscopies after a positive FIT in community clinics
Aims to help people with abnormal stool tests for colorectal cancer get timely follow-up colonoscopies in safety-net clinics.
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Colorectal cancer screening with real-time imaging that may replace sedated scopes
Researchers are testing a new imaging method called optical coherence tomography (OCT) to spot and treat colon polyps without the need for sedation during a screening colonoscopy.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.