AI/AN Tailoring of a Home-Based Cervical and Colorectal Cancer Screening Program
Official title: American Indian/Alaska Native Tailoring of a Home-Based Cervical and Colorectal Cancer Screening Program (AT-HOME)
Funded at Oregon Health & Science University · NIH-11443461 · Data updated 2026-11-12
A tailored, home-based cancer screening program helps AI/AN adults screen for cervical and colorectal cancer from home using self-collection tests and culturally aligned education.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oregon Health & Science University NIH-funded |
| Lab location | 1 site (Portland, United States) |
| Project start | September 1, 2026 |
| Project end | November 30, 2030 |
| Funding year | 2026 |
| Award (this year) | $3,117,935 |
| NIH project number | 1R01MD021852-01 |
| Project ID | NIH-11443461 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults aged 21 years and older in AI/AN communities who are eligible for CC and CRC screening and have access to home-based testing resources.
✕Less likely to help
Individuals who are not due for screening or who do not participate in home-based testing may see little or no direct benefit.
What this research studies
This project aims to increase cervical and colorectal cancer screening among American Indian and Alaska Native communities by adapting and integrating FDA-approved home-based tests into existing screening programs. It uses culturally tailored education and outreach to address barriers and improve acceptance of self-swab HPV testing and fecal immunochemical tests. The approach partners with AI/AN communities to implement messages and workflows that fit local values, with the goal of catching cancers or pre-cancerous conditions earlier. The study will measure uptake, adherence, and potential improvements in screening completion within AI/AN populations served by Oregon Health & Science University’s network.
Why it matters
Potential benefit: If successful, the program could raise screening rates and enable earlier cancer detection among AI/AN people, potentially reducing morbidity and mortality.
How similar studies have gone: Previous studies suggest culturally tailored outreach improves screening uptake, but this project tests a home-based, culturally aligned approach in AI/AN populations.
Where this research is happening
-
Oregon Health & Science University
Portland, United States Active
Researchers
- Principal investigator: Bruegl, Amanda S — Oregon Health & Science University
- Study coordinator: Bruegl, Amanda S
Related research
Other NIH-funded projects on the same topics.
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Improving colorectal cancer screening and follow-up care.
This study is working to help more people get screened for colorectal cancer and receive the follow-up care they need, especially those who haven't been screened much before, so that everyone can have better access to important health checks and improve their overall health.
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Making colorectal cancer screening easier and more likely to happen
This project uses default options, simpler choices, and direct outreach to help average-risk adults who are overdue complete colorectal cancer screening with colonoscopy or stool tests.
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Bringing colorectal cancer screening to adults 45–54 who haven’t been screened
A grant to help low-income adults aged 45–54 start colorectal cancer screening through the Boston area’s community health centers.
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Increasing follow-up colonoscopies after a positive FIT in community clinics
Aims to help people with abnormal stool tests for colorectal cancer get timely follow-up colonoscopies in safety-net clinics.
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Colorectal cancer screening with real-time imaging that may replace sedated scopes
Researchers are testing a new imaging method called optical coherence tomography (OCT) to spot and treat colon polyps without the need for sedation during a screening colonoscopy.
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Promoting follow-up after abnormal colorectal cancer screening in safety-net systems
A multilevel program will help people in safety-net hospitals complete follow-up colonoscopy after an abnormal stool test.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.