Predictors of recovery after stroke in rural Appalachia
Official title: Predictors and Biomarkers for VCID versus Cognitive Recovery after Stroke Thrombectomy in Rural Appalachia
Funded at University of Kentucky · NIH-11362286 · Data updated 2026-11-12
This project tests blood protein markers to predict cognitive recovery after a stroke treated with thrombectomy, focusing on rural Appalachian patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Kentucky NIH-funded |
| Lab location | 1 site (Lexington, United States) |
| Project start | April 15, 2023 |
| Project end | March 31, 2029 |
| Funding year | 2026 |
| Award (this year) | $382,489 |
| NIH project number | 5R01NS127974-04 |
| Project ID | NIH-11362286 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults in rural/underserved communities who had ELVO stroke and are undergoing thrombectomy.
✕Less likely to help
Patients without access to thrombectomy or those not meeting the study’s follow-up criteria may not benefit.
What this research studies
If you’ve had a stroke in a rural area, doctors want to know who will recover cognitively after treatment. The study will collect blood samples during thrombectomy and follow participants for up to two years to see how proteins relate to later thinking skills. Researchers will combine biological data with clinical and social factors to improve predictions beyond current tests. Participants will receive careful follow-up and rehabilitation planning based on the findings.
Why it matters
Potential benefit: If successful, this work could improve personalized recovery plans and rehabilitation timing for stroke patients in underserved areas.
How similar studies have gone: Previous work suggests blood proteins can reflect brain injury and recovery, but this study focuses on a rural, real-world setting with long-term follow-up.
Where this research is happening
-
University of Kentucky
Lexington, United States Active
Researchers
- Principal investigator: Harp, Jordan Patrick — University of Kentucky
- Study coordinator: Harp, Jordan Patrick
Related research
Other NIH-funded projects on the same topics.
-
Robotic ultrasound-guided clot removal for stroke treatment
A new robot-assisted ultrasound system is being developed to help quickly reopen brain arteries during a stroke, with testing in patient-specific 3D-printed models and animal studies.
-
Modeling Acute Ischemic Stroke to Improve Mechanical Thrombectomy
A research project is creating better computer models and animal studies to help remove clots more safely and effectively in people who have an acute ischemic stroke.
-
Predicting Mechanical Thrombectomy Outcomes with Smart, Transparent AI
A patient-friendly look at how new AI models may predict how well mechanical thrombectomy could work for individuals with acute ischemic stroke.
-
Improving stroke treatment with a new catheter device for easier access.
This study is testing a new catheter device that helps doctors remove blood clots in the brain through the wrist instead of the groin, aiming to make the treatment for stroke patients safer and more effective.
-
Improving treatment for acute ischemic stroke using advanced modeling techniques
This study is looking at how blood clots form in the brain and why some can be removed easily while others can't, with the goal of helping doctors improve treatments for people who have had a stroke.
-
Developing a smart catheter to improve blood clot removal in stroke treatment
This study is testing a new smart catheter that helps doctors remove blood clots during stroke treatment by giving them real-time information about how the procedure is going, making it safer and more effective for patients.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.