Pneumococcal Disease and Carriage in Children with Sickle Cell Disease in Ghana
Official title: Invasive Pneumococcal Disease and Carriage among Children with Sickle Cell Disease in Ghana: A Post-vaccination Study
Funded at University of Ghana · NIH-11336917 · Data updated 2026-11-12
This project looks at how often kids with sickle cell disease in Ghana carry and get invasive pneumococcal disease after vaccination.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Ghana NIH-funded |
| Lab location | 1 site (Legon, Ghana) |
| Project start | May 12, 2022 |
| Project end | April 30, 2027 |
| Funding year | 2026 |
| Award (this year) | $99,598 |
| NIH project number | 5R01AI169674-05 |
| Project ID | NIH-11336917 on NIH RePORTER |
Who could benefit from this research
✓Could help
Children with sickle cell disease in Ghana, especially those under 5 years old, who have received pneumococcal vaccination.
✕Less likely to help
Children without sickle cell disease or those not within the study region or age range may not directly benefit.
What this research studies
This study follows children with sickle cell disease in Ghana to map how pneumococcus bacteria are carried and how often invasive disease occurs after PCV introduction. Researchers will collect samples to identify carriage rates and track instances of serious illness, in the post-vaccine era. The work aims to inform vaccination and prophylaxis strategies to protect vulnerable kids in sub-Saharan Africa. Results could help tailor public health policies and vaccination schedules for children with SCD in similar settings.
Why it matters
Potential benefit: Understanding carriage and disease patterns could lead to better protection for children with sickle cell disease through optimized vaccination and prophylaxis.
How similar studies have gone: Prior work shows that pneumococcal vaccination shifts serotype distribution and affects carriage, but post-vaccine data in SCD populations in Africa are limited and informative.
Where this research is happening
-
University of Ghana
Legon, Ghana Active
Researchers
- Principal investigator: Sampane-Donkor, Eric — University of Ghana
- Study coordinator: Sampane-Donkor, Eric
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.