Investigating pneumococcal disease in children with sickle cell disease in Ghana after vaccination
Official title: Invasive Pneumococcal Disease and Carriage among Children with Sickle Cell Disease in Ghana: A Post-vaccination Study
Funded at University of Ghana · NIH-11134547 · Data updated 2026-11-12
This study is looking at how pneumococcal bacteria impact children with sickle cell disease in Ghana after they received a vaccine, to see how often these bacteria are found and if there are any changes in serious infections, so we can better protect and treat these kids.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Ghana NIH-funded |
| Lab location | 1 site (Legon, Ghana) |
| Project start | May 12, 2022 |
| Project end | April 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $123,489 |
| NIH project number | 5R01AI169674-04 |
| Project ID | NIH-11134547 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children under 11 years old diagnosed with sickle cell disease living in Ghana.
✕Less likely to help
Patients who do not have sickle cell disease or are outside the age range of 0-11 years may not benefit from this research.
What this research studies
This research focuses on understanding how pneumococcal bacteria affect children with sickle cell disease (SCD) in Ghana after the introduction of pneumococcal conjugate vaccines. It aims to assess the frequency of pneumococcal carriage and the incidence of invasive pneumococcal disease among these children. By collecting and analyzing data on the types of pneumococcal bacteria present, the study seeks to identify any changes in disease patterns following vaccination. This information will help improve preventive measures and treatment strategies for vulnerable children.
Why it matters
Potential benefit: If successful, this research could lead to better prevention and treatment strategies for invasive pneumococcal disease in children with sickle cell disease.
How similar studies have gone: Previous research has shown that pneumococcal conjugate vaccines can significantly impact disease patterns, indicating potential success for this study's approach.
Where this research is happening
-
University of Ghana
Legon, Ghana Active
Researchers
- Principal investigator: Sampane-Donkor, Eric — University of Ghana
- Study coordinator: Sampane-Donkor, Eric
Related research
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Pneumococcal Disease and Carriage in Children with Sickle Cell Disease in Ghana
This project looks at how often kids with sickle cell disease in Ghana carry and get invasive pneumococcal disease after vaccination.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.