Understanding how low oxygen levels during pregnancy affect newborn lung health
Official title: Mechanisms of newborn pulmonary hypertension caused by chronic intrauterine hypoxia
Funded at Loma Linda University · NIH-10993588 · Data updated 2026-11-12
This study is looking at how not getting enough oxygen in the womb might cause high blood pressure in the lungs of newborns, and it aims to understand how a certain part of the lungs works to help with blood flow, which could lead to better treatments for babies who are affected.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Loma Linda University NIH-funded |
| Lab location | 1 site (Loma Linda, UNITED STATES) |
| Project start | January 1, 2022 |
| Project end | November 30, 2025 |
| Funding year | 2025 |
| Award (this year) | $686,870 |
| NIH project number | 5R01HL155295-04 |
| Project ID | NIH-10993588 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are newborns who have been exposed to chronic low oxygen conditions during pregnancy, such as those born to mothers with preeclampsia or who live at high altitudes.
✕Less likely to help
Patients who are not newborns or who do not have a history of exposure to chronic intrauterine hypoxia may not benefit from this research.
What this research studies
This research investigates how chronic low oxygen levels in the womb can lead to pulmonary hypertension in newborns. It focuses on the role of a specific channel in the lungs that helps regulate blood flow and how its dysfunction may be linked to low oxygen conditions. By using both laboratory and animal models, the researchers aim to uncover the biological mechanisms behind this condition, which could lead to new treatment strategies for affected infants.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for newborns suffering from pulmonary hypertension caused by low oxygen exposure during pregnancy.
How similar studies have gone: Previous research has shown promising results in understanding the mechanisms of pulmonary hypertension related to hypoxia, indicating that this approach has potential for success.
Where this research is happening
-
Loma Linda University
Loma Linda, United States Active
Researchers
- Principal investigator: Blood, Arlin B — Loma Linda University
- Study coordinator: Blood, Arlin B
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.