Obesity and GLP-1 treatment in young people with type 1 diabetes
Official title: Obesity complicating type 1 diabetes in young people: Physiology and Impact of GLP-1 analogue anti-obesity treatment on cardiometabolic risk factors
Funded at Yale University · NIH-11370619 · Data updated 2026-11-12
A study in teens and young adults with type 1 diabetes and obesity will look at how a GLP-1–based obesity medicine affects body fat distribution, insulin resistance, and lipids.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | September 1, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2026 |
| Award (this year) | $724,474 |
| NIH project number | 5R01DK134398-04 |
| Project ID | NIH-11370619 on NIH RePORTER |
Who could benefit from this research
✓Could help
Young people with type 1 diabetes and obesity who can participate in imaging and metabolic testing.
✕Less likely to help
Patients without obesity or without access to GLP-1–based obesity treatment may not benefit directly.
What this research studies
This project focuses on understanding how a GLP-1 analogue for obesity changes cardiometabolic risk factors in young people with type 1 diabetes and obesity. Researchers will measure visceral fat versus subcutaneous fat, insulin resistance, and post-meal lipid responses using MRI, clamp tests with stable isotopes, DEXA scans, and a high-fat meal test. The goal is to uncover mechanisms that link obesity, diabetes, and cardiovascular risk in this population and to see how this treatment modulates those pathways. Findings could guide personalized strategies to reduce future heart and metabolic complications for youth living with both conditions.
Why it matters
Potential benefit: If successful, the work could lead to more effective obesity management in youth with type 1 diabetes and lower future cardiovascular risk.
How similar studies have gone: Preliminary data suggest links between visceral fat, hepatic insulin resistance, and metabolism in this population; this study adds targeted intervention.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Van Name, Michelle — Yale University
- Study coordinator: Van Name, Michelle
Related research
Other NIH-funded projects on the same topics.
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Understanding and treating obesity in young people with type 1 diabetes
This research explores how a medication for obesity, called a GLP-1 analogue, helps young people with type 1 diabetes manage their weight and reduce heart-related health risks.
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Investigating the effects of a medication for obesity on heart and metabolic health in young people with type 1 diabetes
This study is looking at how a special medication can help young people with type 1 diabetes manage their weight and improve their health, by checking things like body fat and how their bodies use insulin.
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Low-cost, heat-stable GLP-1 and GIP receptor agonists produced in maize for diabetes and obesity
This project aims to make affordable, heat-stable versions of diabetes and obesity medicines using corn plants.
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Understanding what raises heart disease risk in people with well-controlled type 1 diabetes
Researchers are studying why some people with type 1 diabetes still develop heart disease even when traditional risk factors are controlled.
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Comparing bariatric (weight‑loss) surgery with GLP‑1 and SGLT‑2 diabetes medicines for people with obesity and type 2 diabetes
This project compares long-term benefits and safety of weight‑loss surgery versus GLP‑1 and SGLT‑2 diabetes medicines for adults who have obesity and type 2 diabetes.
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Understanding Heart Disease Risks in People with Well-Controlled Type 1 Diabetes
This project looks at why people with Type 1 diabetes might still get heart disease, even when their other health factors are well-managed.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.