Novel ways to keep organs functioning in sepsis
Official title: Novel Approaches to Maintaining Organ Function in Sepsis
Funded at Feinstein Institute for Medical Research · NIH-11361593 · Data updated 2026-11-12
A cancer-style grant is helping scientists understand how to prevent organ failure in people with sepsis by studying immune cells and their signals.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Feinstein Institute for Medical Research NIH-funded |
| Lab location | 1 site (Manhasset, United States) |
| Project start | June 1, 2016 |
| Project end | June 30, 2027 |
| Funding year | 2026 |
| Award (this year) | $508,781 |
| NIH project number | 5R35GM118337-10 |
| Project ID | NIH-11361593 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with sepsis or septic shock who are at risk of acute lung injury.
✕Less likely to help
This research focuses on mechanisms in the immune system and may not directly benefit healthy individuals.
What this research studies
This program looks at how neutrophils—white blood cells—become overactive in sepsis and damage lungs. Researchers are exploring how a molecule called eCIRP fuels inflammation and how a special neutrophil group (APANs) may drive harmful responses. The work uses advanced biological models to uncover how these cells behave and interact with the lungs during sepsis. The goal is to identify new targets to reduce lung injury and improve survival for patients with septic shock.
Why it matters
Potential benefit: If successful, this work could lead to new therapies that lessen lung damage and death from sepsis.
How similar studies have gone: Previous findings show neutrophil-driven inflammation plays a key role in sepsis; this study builds on that by detailing a novel neutrophil subset and its effects.
Where this research is happening
-
Feinstein Institute for Medical Research
Manhasset, United States Active
Researchers
- Principal investigator: Wang, Ping — Feinstein Institute for Medical Research
- Study coordinator: Wang, Ping
Related research
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.