Molecular clues to daily blood pressure changes and heart disease
Official title: Molecular Determinants of Dynamic Blood Pressure Regulation and Cardiovascular Disease
Funded at Beth Israel Deaconess Medical Center · NIH-11432118 · Data updated 2026-11-12
Researchers are exploring how dynamic blood pressure changes throughout daily life relate to heart disease, with new protein measurements to identify potential targets for better control.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Beth Israel Deaconess Medical Center NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | September 1, 2026 |
| Project end | May 31, 2031 |
| Funding year | 2026 |
| Award (this year) | $853,092 |
| NIH project number | 1R01HL188729-01 |
| Project ID | NIH-11432118 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults 21 years and older with hypertension or at risk for cardiovascular disease, who can provide blood samples and participate in genetic/proteomic analyses.
✕Less likely to help
Individuals without hypertension or cardiovascular risk who do not experience improvements in blood pressure management may not benefit directly.
What this research studies
This project looks at why blood pressure varies during stress and aging, using high-throughput blood protein measurements to connect these dynamic patterns with biology. By combining genetic information with proteomic data, the study aims to uncover mechanisms that drive blood pressure regulation beyond single resting readings. The goal is to identify new targets that could lead to more effective, personalized treatments for hypertension and cardiovascular disease.
Why it matters
Potential benefit: If successful, findings could lead to new treatment targets and better strategies to keep blood pressure in a healthy range, reducing heart disease risk.
How similar studies have gone: Previous work linking dynamic blood pressure patterns to cardiovascular risk is growing, with some proteomic-genetic integrations showing promise but requiring further validation.
Where this research is happening
-
Beth Israel Deaconess Medical Center
Boston, United States Active
Researchers
- Principal investigator: Tahir, Usman a. — Beth Israel Deaconess Medical Center
- Study coordinator: Tahir, Usman a.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.