Investigating how a fat-derived protein affects blood pressure and heart health
Official title: Role of Vascular Chemerin as a Regulator of Blood Pressure and Contributor to Cardiovascular Disease
Funded at Henry Ford Health + Michigan State University Health Sciences · NIH-10900228 · Data updated 2026-11-12
This study is looking at how a protein called chemerin, made in fat tissue, affects blood pressure and heart health, especially for people dealing with high blood pressure due to obesity, to see if blocking chemerin can help lower blood pressure.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Henry Ford Health + Michigan State University Health Sciences NIH-funded |
| Lab location | 1 site (East Lansing, United States) |
| Project start | January 1, 2025 |
| Project end | December 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $43,690 |
| NIH project number | 1F31HL173985-01 |
| Project ID | NIH-10900228 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from obesity-related hypertension or those at risk of developing cardiovascular diseases.
✕Less likely to help
Patients who do not have obesity or hypertension may not benefit from this research.
What this research studies
This research focuses on understanding the role of a protein called chemerin, which is produced in fat tissue, in regulating blood pressure and contributing to cardiovascular diseases. The study examines how chemerin affects blood vessels and blood pressure, particularly in the context of obesity-related hypertension. By using specific techniques to inhibit chemerin, researchers aim to determine its impact on blood pressure levels in animal models. The findings could lead to new treatments for hypertension associated with obesity.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that effectively lower blood pressure in patients with obesity-related hypertension.
How similar studies have gone: Previous research has shown promising results in targeting similar pathways for blood pressure regulation, indicating potential for success in this approach.
Where this research is happening
-
Henry Ford Health + Michigan State University Health Sciences
East Lansing, United States Active
Researchers
- Principal investigator: Wabel, Emma — Henry Ford Health + Michigan State University Health Sciences
- Study coordinator: Wabel, Emma
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.