Mitochondrial issues causing liver problems in Hispanic adults with leukemia treatment
Mitochondrial Dysfunction underlies treatment related hepatotoxicity in Hispanics with acute lymphoblastic leukemia
This study is looking at how problems with tiny parts of our cells, called mitochondria, might make liver issues more likely in Hispanic adults being treated for acute lymphoblastic leukemia, so we can find better ways to personalize their treatment and help them feel better.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Southern California NIH-funded |
| Lab location | 1 site (Los Angeles, UNITED STATES) |
| Project ID | NIH-10675403 on NIH RePORTER |
What this research studies
This research investigates how mitochondrial dysfunction contributes to liver toxicity in Hispanic patients undergoing treatment for acute lymphoblastic leukemia (ALL). The study focuses on understanding the genetic factors that may increase the risk of hepatotoxicity, particularly in adults, as they often experience more severe side effects from treatments like asparaginase. By examining the genetic variants associated with mitochondrial function, the research aims to identify potential biomarkers that could help tailor treatment plans and improve outcomes for this population. The approach includes pharmacogenomic analysis to better understand how these factors affect treatment efficacy and safety.
Who could benefit from this research
Good fit: Ideal candidates for this research are Hispanic adults diagnosed with acute lymphoblastic leukemia who are undergoing treatment.
Not a fit: Patients who are not Hispanic or those who do not have acute lymphoblastic leukemia may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to safer and more effective treatment strategies for Hispanic patients with acute lymphoblastic leukemia.
How similar studies have performed: Previous research has shown that genetic factors can influence treatment outcomes in cancer, but this specific focus on Hispanic populations and mitochondrial dysfunction is relatively novel.
Where this research is happening
Los Angeles, UNITED STATES
- University of Southern California — Los Angeles, United States (Active)
Researchers
- Principal investigator: Alachkar, Houda — University of Southern California
- Study coordinator: Alachkar, Houda
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.