KPoP: Preventing CMV in kidney transplant recipients with D+R- risk
Official title: Kidney transplant Preemptive therapy or Prophylaxis (KPoP) for CMVPreventionin D+R- Recipients
Funded at University of California, San Francisco · NIH-11337540 · Data updated 2026-11-12
A kidney transplant study tests a preemptive approach to prevent CMV disease in patients who received a donor organ from a CMV-positive donor and are CMV seronegative.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | July 12, 2024 |
| Project end | May 31, 2031 |
| Funding year | 2026 |
| Award (this year) | $1,682,241 |
| NIH project number | 5R01AI184205-04 |
| Project ID | NIH-11337540 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults (21+ years) who have received a kidney transplant from a CMV-positive donor and are CMV seronegative.
✕Less likely to help
Patients not meeting the D+R- CMV risk profile or who choose different transplantation strategies may not benefit.
What this research studies
This project targets adults who have received a kidney transplant and are CMV seronegative but received a donor organ from a CMV-positive person. It compares preemptive CMV strategies to prevent disease after transplantation, focusing on immune responses and antiviral use. By tracking CMV DNA levels and clinical outcomes, the study aims to optimize timing and choice of antiviral therapy to spare patients unnecessary drug exposure while protecting graft health. The work will be conducted at the University of California, San Francisco, led by Dr. Abhijit Prakash Limaye, and involves long-term follow-up through 2031.
Why it matters
Potential benefit: If successful, patients could experience fewer CMV-related illnesses and better graft survival with more tailored antiviral strategies.
How similar studies have gone: An analogous liver transplant trial showed PET reduced antiviral exposure and CMV disease, supporting exploration in kidney transplantation with ATG use.
Where this research is happening
-
University of California, San Francisco
San Francisco, United States Active
Researchers
- Principal investigator: Limaye, Abhijit Prakash — University of California, San Francisco
- Study coordinator: Limaye, Abhijit Prakash
Related research
Other NIH-funded projects on the same topics.
-
Microbial clues to diagnose and predict infections in kidney transplant patients
A patient-focused project will look for microbial biomarkers in stool, blood, and urine to help doctors predict and diagnose infections in people who have had a kidney transplant.
-
Immunological mechanisms behind treatment-resistant kidney transplant rejection
This grant explores why certain kidney transplant rejections don’t respond to standard treatments and what immune cells in the graft are driving that resistance.
-
Complement-Bound Exosomes and Kidney Transplant Immunity
This project studies how kidney transplant injury and rejection happen after surgery and whether blocking certain immune pathways during organ preservation could improve transplant outcomes.
-
Blood vessel signals predicting heart problems after kidney transplant
This project studies blood markers and tissue patterns after kidney transplants to identify which patients are at highest risk of cardiovascular problems.
-
Understanding how BK virus links infection to kidney transplant rejection
This project looks at how BK polyomavirus reactivation affects kidney transplant patients and aims to use pre-transplant T cell information to tailor immunosuppression and monitoring.
-
Characterization of a LILRB3 SNP cluster and its link to kidney transplant outcomes
A study in kidney transplant recipients looks at genetic factors that may be tied to higher risk of graft failure.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.