Characterization of a LILRB3 SNP cluster and its link to kidney transplant outcomes

Who could benefit from this research

What this research studies

This project will examine a cluster of LILRB3 gene SNPs that have been linked to poorer kidney transplant results by analyzing patient blood and transplant data across multiple centers. Researchers will relate genetic variants to immune signaling pathways and kidney function after transplantation. The goal is to understand whether these genetic differences help explain why some patients experience graft failure despite similar clinical factors. The study builds on previous findings and will use RNA sequencing and clinical data to explore these associations. Results could point toward new biomarkers or targets to improve graft survival for affected patients.

Why it matters

Where this research is happening

• Icahn School of Medicine at Mount Sinai
  New York, United States Active

Researchers

• Principal investigator: Zhang, Weijia — Icahn School of Medicine at Mount Sinai
• Study coordinator: Zhang, Weijia

Related research

Other NIH-funded projects on the same topics.

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• Complement-Bound Exosomes and Kidney Transplant Immunity

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• Blood vessel signals predicting heart problems after kidney transplant

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  NIH research Yale University · New Haven, United States · NIH-11441506

• Understanding how BK virus links infection to kidney transplant rejection

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  NIH research University of California, San Diego · La Jolla, United States · NIH-11436797

• Optimizing a prehabilitation program for kidney transplant candidates on dialysis

  A program to improve physical function and readiness for kidney transplant in people on dialysis is being developed and tested to help candidates stay healthier while they wait.

  NIH research New York University School of Medicine · New York, United States · NIH-11421433

About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.