Kidney transplantation from HIV-positive donors to HIV-positive recipients
Official title: Kidney Transplantation from Donors with HIV: Impact on Rejection and Long-term Outcomes
Funded at Johns Hopkins University · NIH-11082518 · Data updated 2026-11-12
This study is looking at how well kidney transplants from HIV-positive donors work for people who also have HIV, to see if they have better or worse outcomes compared to transplants from HIV-negative donors, all to help improve care for patients like you.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | May 25, 2023 |
| Project end | April 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $1,715,945 |
| NIH project number | 5U01AI177211-03 |
| Project ID | NIH-11082518 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are HIV-positive individuals in need of a kidney transplant.
✕Less likely to help
Patients who are HIV-negative or those who do not require a kidney transplant may not benefit from this research.
What this research studies
This research investigates the outcomes of kidney transplantation from donors with HIV to recipients who also have HIV. It aims to understand the rates of organ rejection and the long-term health impacts of such transplants. By comparing the outcomes of these transplants with those from HIV-negative donors, the study seeks to identify the underlying mechanisms of rejection and improve patient care. The research will involve a multicenter trial with 200 participants across 15 transplant centers, leveraging existing data from previous cohorts.
Why it matters
Potential benefit: If successful, this research could lead to improved kidney transplant outcomes for HIV-positive patients, expanding their access to life-saving organs.
How similar studies have gone: Previous studies under the HOPE Act have shown promising results in expanding the donor pool and improving short-term outcomes for HIV-positive transplant recipients.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Durand, Christine Marie — Johns Hopkins University
- Study coordinator: Durand, Christine Marie
Related research
Other NIH-funded projects on the same topics.
-
Kidney transplants from HIV-positive donors: impact on rejection and long-term outcomes
This study will compare kidney transplant outcomes for HIV-positive donor to HIV-positive recipient transplants versus HIV-negative donor transplants in people living with HIV.
-
Strategies for HIV-to-HIV kidney transplants to increase organ donations
This project looks at making HIV-to-HIV kidney transplantation more common to help people with HIV get transplants faster by boosting organ donation and changing practice.
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Biomarker-guided Immunosuppression in Kidney Transplant Patients
A multicenter study in kidney transplant recipients is testing whether a biomarker score from HLA-DR/DQ can guide changes in immunosuppression to reduce rejection risk and drug toxicity.
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Helping the immune system accept a donated kidney in patients without prior sensitization
This project will try giving specially treated donor B cells alongside immune-sparing medicines to teach the immune systems of kidney transplant patients without prior antibodies to accept the new kidney.
-
Lowering donor-specific antibodies in sensitized kidney transplant patients
This project works to reduce harmful donor-specific antibodies in people who are sensitized and need a kidney transplant so their new organ lasts longer.
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Injecting immune-boosting medicine into melanoma tumors to help the immune system reject them
This gives an immune-boosting drug directly into melanoma tumors in pet dogs to help their T cells find and destroy the cancer.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.