Kidney transplantation from HIV-positive donors to HIV-positive recipients
Kidney Transplantation from Donors with HIV: Impact on Rejection and Long-term Outcomes
This study is looking at how well kidney transplants from HIV-positive donors work for people who also have HIV, to see if they have better or worse outcomes compared to transplants from HIV-negative donors, all to help improve care for patients like you.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-11082518 on NIH RePORTER |
What this research studies
This research investigates the outcomes of kidney transplantation from donors with HIV to recipients who also have HIV. It aims to understand the rates of organ rejection and the long-term health impacts of such transplants. By comparing the outcomes of these transplants with those from HIV-negative donors, the study seeks to identify the underlying mechanisms of rejection and improve patient care. The research will involve a multicenter trial with 200 participants across 15 transplant centers, leveraging existing data from previous cohorts.
Who could benefit from this research
Good fit: Ideal candidates for this research are HIV-positive individuals in need of a kidney transplant.
Not a fit: Patients who are HIV-negative or those who do not require a kidney transplant may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved kidney transplant outcomes for HIV-positive patients, expanding their access to life-saving organs.
How similar studies have performed: Previous studies under the HOPE Act have shown promising results in expanding the donor pool and improving short-term outcomes for HIV-positive transplant recipients.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Durand, Christine Marie — Johns Hopkins University
- Study coordinator: Durand, Christine Marie
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.