Ischemia-protective effects of anesthetic conditioning after brain bleed
Official title: Molecular mechanisms underlying isoflurane conditioning-induced neurovascular protection in subarachnoid hemorrhage
Funded at Washington University · NIH-11364112 · Data updated 2026-11-12
This grant studies how certain anesthetics might protect the brain after an aneurysmal brain bleed to improve recovery prospects.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | July 15, 2022 |
| Project end | June 30, 2027 |
| Funding year | 2026 |
| Award (this year) | $174,360 |
| NIH project number | 5K08NS125038-05 |
| Project ID | NIH-11364112 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are individuals with or at risk for aneurysmal SAH or related brain injuries who may benefit from future neuroprotective strategies derived from anesthetic conditioning research.
✕Less likely to help
Early-stage, non-neurological patients or those without SAH-related brain injury may not benefit from this research.
What this research studies
Researchers will study how conditioning the brain with anesthetic drugs could shield the brain's blood vessels and cells after a subarachnoid hemorrhage. The work combines animal models, molecular biology, and functional imaging to understand the protective mechanisms and behavior after injury. The goal is to translate these insights into new therapeutic approaches for SAH and other brain injuries, with hands-on training in SAH models and neuroimaging. This is led by Dr. Athiraman at Washington University and supported by mentors in anesthesiology and neurosurgery.
Why it matters
Potential benefit: If successful, the project could lead to new treatments that reduce brain injury after aneurysmal SAH and improve recovery.
How similar studies have gone: Preclinical studies in this area have shown protective effects in animal models, with translation to humans still under investigation.
Where this research is happening
-
Washington University
Saint Louis, United States Active
Researchers
- Principal investigator: Athiraman, Umeshkumar — Washington University
- Study coordinator: Athiraman, Umeshkumar
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.