IOP and CSF Pressure Factors in Glaucoma
Official title: IOP and Cerebrospinal Fluid Pressure-related Risk Factors for Glaucoma
Funded at University of Alabama at Birmingham · NIH-11345220 · Data updated 2026-11-12
A patient-focused look at how eye pressure and surrounding fluid pressure may influence glaucoma risk and progression.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Alabama at Birmingham NIH-funded |
| Lab location | 1 site (Birmingham, United States) |
| Project start | December 1, 2015 |
| Project end | May 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $740,628 |
| NIH project number | 5R01EY026035-09 |
| Project ID | NIH-11345220 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults 21 years and older who may be affected by glaucoma or are at risk, including patients undergoing eye pressure monitoring.
✕Less likely to help
Individuals without glaucoma risk factors or those not involved in pressure-related studies may see limited direct benefit.
What this research studies
This project investigates how the pressure inside the eye and the fluid around the optic nerve interact to affect glaucoma, with a focus on the nerve fibers that transmit vision. Researchers study the lamina cribrosa and how its stiffness and thickness influence pressure distribution at the optic nerve head. The goal is to understand why some people with similar eye pressures develop glaucoma while others do not, which may lead to personalized prevention and treatment strategies.
Why it matters
Potential benefit: Better understanding of who is at risk and why could lead to more precise glaucoma prevention and management.
How similar studies have gone: Previous studies suggest a link between intraocular pressure, CSF pressure, and glaucoma, but continuous measurement and individual variation remain areas to clarify.
Where this research is happening
-
University of Alabama at Birmingham
Birmingham, United States Active
Researchers
- Principal investigator: Downs, J Crawford — University of Alabama at Birmingham
- Study coordinator: Downs, J Crawford
Related research
Other NIH-funded projects on the same topics.
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IOP and CSF Pressure in Glaucoma Risk
This grant studies how eye pressure and cerebrospinal fluid pressure together influence glaucoma risk and vision loss.
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Using a smart eye emulator to understand glaucoma risk factors
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.