NIH-funded research R01 grant

Using a smart eye emulator to understand glaucoma risk factors

Official title: SCH: SEEthroughGLAUCOMA: Smart Eye Emulator (SEE) to study glaucoma risk factors

Funded at University of Maine Orono · NIH-10930934 · Data updated 2026-11-12

This study is looking at what factors might increase the risk of open angle glaucoma, so we can create a smart tool to help doctors better understand who needs more attention and who might not need as much treatment, making it easier for everyone to get the right care.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionUniversity of Maine Orono
NIH-funded
Lab location1 site (Orono, United States)
Project startSeptember 1, 2022
Project endJune 30, 2026
Funding year2024
Award (this year)$225,049
NIH project number5R01EY034718-04
Project IDNIH-10930934 on NIH RePORTER

Who could benefit from this research

Could help

Ideal candidates for this research include individuals at risk for open angle glaucoma, particularly those with varying blood pressure and intraocular pressure levels.

Less likely to help

Patients with other types of glaucoma or those who do not have risk factors associated with open angle glaucoma may not benefit from this research.

What this research studies

This research investigates the risk factors associated with open angle glaucoma (OAG), a leading cause of irreversible blindness. It aims to develop a smart eye emulator that can accurately estimate the contributions of intraocular pressure (IOP) and blood pressure (BP) along with demographic factors like age, gender, and race. By quantifying these risk factors, the research seeks to create a framework that helps clinicians provide targeted care to patients at higher risk while avoiding unnecessary treatments for those at lower risk. The approach combines advanced computer modeling with clinical data analysis to enhance understanding and management of glaucoma.

Why it matters

Potential benefit: If successful, this research could lead to more personalized and effective treatment strategies for glaucoma patients.

How similar studies have gone: Previous research has shown promise in using computer models to analyze risk factors for various diseases, suggesting that this approach could yield valuable insights for glaucoma management.

Where this research is happening

  • University of Maine Orono
    Orono, United States
    Active

Researchers

  • Principal investigator: Guidoboni, Giovanna — University of Maine Orono
  • Study coordinator: Guidoboni, Giovanna

Related research

Other NIH-funded projects on the same topics.

  • IOP and CSF Pressure in Glaucoma Risk

    This grant studies how eye pressure and cerebrospinal fluid pressure together influence glaucoma risk and vision loss.

    NIH research University of Alabama at Birmingham · Birmingham, United States · NIH-11644421

  • IOP and CSF Pressure Factors in Glaucoma

    A patient-focused look at how eye pressure and surrounding fluid pressure may influence glaucoma risk and progression.

    NIH research University of Alabama at Birmingham · Birmingham, United States · NIH-11345220

  • Smart Eye Emulator to understand glaucoma risk

    This project builds a computer 'eye emulator' to explain how eye pressure, blood pressure, age, and race influence glaucoma risk for people with or at risk for open-angle glaucoma.

    NIH research University of Maine Orono · Orono, United States · NIH-11182599

  • How genes and everyday exposures affect risk of exfoliation syndrome and glaucoma

    Looks at whether genetic differences and common exposures like sunlight and coffee change the chance of exfoliation syndrome and related glaucoma for people at risk of vision loss.

    NIH research Massachusetts Eye and Ear Infirmary · Boston, United States · NIH-11138698

  • Understanding Eye and Brain Pressure in Glaucoma

    This research aims to better understand how pressure inside the eye and around the brain contributes to glaucoma and vision loss.

    NIH research University of Alabama at Birmingham · Birmingham, United States · NIH-11099939

  • ALS risk factors in a long-term ALS study

    A long-term ALS study is looking at which factors may influence disease risk and progression in people living with ALS.

    NIH research Als Therapy Development Foundation · Watertown, United States · NIH-11631679

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.