Integrating urine isoniazid testing into routine TB care to spot nonadherence
Official title: Integrating point-of-care urine isoniazid testing into routine care for tuberculosis disease to detect medication nonadherence and improve treatment outcomes
Funded at Tufts University Boston · NIH-11458759 · Data updated 2026-11-12
A clinician-facing test using urine isoniazid at regular TB clinic visits helps detect whether people are taking their TB medicines, with the aim of preventing death, recurrence, and drug resistance.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Tufts University Boston NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | August 7, 2025 |
| Project end | July 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $120,852 |
| NIH project number | 3R01AI182659-02S1 |
| Project ID | NIH-11458759 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with active TB who are receiving routine care and are able to provide urine samples at scheduled visits.
✕Less likely to help
Patients who are not on a full TB treatment plan or who are unable to provide urine samples may not benefit.
What this research studies
This project will test how a simple urine urine isoniazid check works when used during normal TB clinic visits. It combines clinical data, patient behaviors, and implementation science to see how best to use the test to improve care. The study follows people with TB over time to identify barriers, facilitators, and real-world effectiveness of the test in guiding differentiated support. By understanding both how the test performs and why patients may miss doses, the team aims to integrate this tool smoothly into routine practice.
Why it matters
Potential benefit: If successful, doctors can quickly identify patients at risk of poor TB outcomes and offer intensified support to keep them adherent to treatment.
How similar studies have gone: Previous tests of urine isoniazid show promise, but this project tests integration into routine care and its effect on outcomes.
Where this research is happening
-
Tufts University Boston
Boston, United States Active
Researchers
- Principal investigator: Subbaraman, Ramnath — Tufts University Boston
- Study coordinator: Subbaraman, Ramnath
Related research
Other NIH-funded projects on the same topics.
-
Coronary disease and immune activation in people with HIV and tuberculosis coinfection
This research looks at how having HIV and latent tuberculosis together might raise the risk of heart disease, and what immune changes are involved.
-
Pulmonary rehabilitation to reduce breathing problems after tuberculosis
A program of guided exercise and breathing training to help adults who have recovered from TB breathe better and feel healthier.
-
Pulmonary rehab to reduce breathing troubles after TB
A program of pulmonary rehabilitation is being studied to help adults who have completed TB treatment avoid ongoing lung problems and improve daily breathing.
-
Air pollution and tuberculosis spread in Kampala, Uganda
This project looks at whether dirty air from PM2.5 particles makes tuberculosis more likely to spread within urban slum households in Kampala, Uganda.
-
Air pollution and TB spread in Ugandan urban slums
This project explores whether exposure to air pollution makes tuberculosis more likely to spread within households in a crowded Ugandan slum.
-
Air pollution and TB transmission in Kampala’s urban slums
This project looks at whether air pollution from PM2.5 makes tuberculosis spread more easily from infected people to their neighbors in urban slums of Kampala, Uganda.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.