Integrated Coagulation Sensing to Predict Bleeding and Guide Transfusions
Official title: Integrated Coagulation Sensing to Predict Hemorrhage and Guide Transfusions
Funded at Massachusetts General Hospital · NIH-11397226 · Data updated 2026-11-12
A patient-focused program to use a new blood-clotting profile tool (iCoagLAB) to help doctors predict bleeding risk and guide transfusion decisions for people on ECMO.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | August 15, 2018 |
| Project end | June 30, 2029 |
| Funding year | 2026 |
| Award (this year) | $720,506 |
| NIH project number | 5R01HL142272-06 |
| Project ID | NIH-11397226 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with acute heart failure on ECMO support or at high risk of hemorrhage or thrombosis.
✕Less likely to help
Patients not undergoing ECMO or without coagulopathy concerns may not benefit from this diagnostic approach.
What this research studies
This grant aims to develop and test iCoagLAB, a homegrown coagulation profiler, as a companion diagnostic during ECMO support in patients with severe heart failure. It includes prospective clinical studies to see if the test can predict who will bleed or clot, helping clinicians balance anticoagulation and transfusion needs. The work addresses the heavy bleeding risk and the complexity of coagulation in ECMO patients, with an emphasis on reducing unnecessary blood draws and improving outcomes. Patients would be enrolled in ECMO programs at participating centers to evaluate how iCoagLAB results correlate with real-world bleeding events and transfusion requirements.
Why it matters
Potential benefit: If successful, patients on ECMO could have safer anticoagulation and more targeted transfusion guidance, potentially reducing bleeding complications and improving survival.
How similar studies have gone: Previous work shows coagulation profiling can help predict bleeding risk, but this project seeks to validate a real-time, ECMO-specific tool.
Where this research is happening
-
Massachusetts General Hospital
Boston, United States Active
Researchers
- Principal investigator: Nadkarni, Seemantini K — Massachusetts General Hospital
- Study coordinator: Nadkarni, Seemantini K
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.