Improving blood sample processing methods for studying sepsis
Official title: Optimizing methods of clinical sample processing for scRNA-seq and mechanistic studies in sepsis to enable reliable, reproducible, and high-yield multi-center collection efforts
Funded at Massachusetts General Hospital · NIH-11228618 · Data updated 2026-11-12
This study is looking at how to improve the way we analyze blood samples from people with sepsis, a serious infection-related condition, to better understand their immune responses and help doctors provide more personalized treatments.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | January 1, 2023 |
| Project end | December 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $676,179 |
| NIH project number | 4R33GM148826-03 |
| Project ID | NIH-11228618 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with sepsis or at risk of developing sepsis.
✕Less likely to help
Patients with conditions unrelated to sepsis or those who do not require hospitalization may not benefit from this research.
What this research studies
This research focuses on enhancing the processing of clinical blood samples to better understand sepsis, a serious condition caused by the body's response to infection. By utilizing advanced techniques like single-cell RNA sequencing (scRNA-seq), the study aims to identify specific immune cell responses in sepsis patients, which can vary widely. The goal is to create a reliable method for collecting and analyzing samples across multiple centers, ultimately leading to more accurate diagnoses and treatments for sepsis. Patients' immune responses will be characterized in detail, helping to tailor therapies to individual needs.
Why it matters
Potential benefit: If successful, this research could lead to more precise and effective treatments for sepsis, improving patient outcomes.
How similar studies have gone: Previous research has successfully utilized single-cell RNA sequencing to identify immune responses in various conditions, indicating a promising approach for sepsis as well.
Where this research is happening
-
Massachusetts General Hospital
Boston, United States Active
Researchers
- Principal investigator: Filbin, Michael — Massachusetts General Hospital
- Study coordinator: Filbin, Michael
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.