Improving blood sample processing methods for studying sepsis
Optimizing methods of clinical sample processing for scRNA-seq and mechanistic studies in sepsis to enable reliable, reproducible, and high-yield multi-center collection efforts
This study is looking at how to improve the way we analyze blood samples from people with sepsis, a serious infection-related condition, to better understand their immune responses and help doctors provide more personalized treatments.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11228618 on NIH RePORTER |
What this research studies
This research focuses on enhancing the processing of clinical blood samples to better understand sepsis, a serious condition caused by the body's response to infection. By utilizing advanced techniques like single-cell RNA sequencing (scRNA-seq), the study aims to identify specific immune cell responses in sepsis patients, which can vary widely. The goal is to create a reliable method for collecting and analyzing samples across multiple centers, ultimately leading to more accurate diagnoses and treatments for sepsis. Patients' immune responses will be characterized in detail, helping to tailor therapies to individual needs.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with sepsis or at risk of developing sepsis.
Not a fit: Patients with conditions unrelated to sepsis or those who do not require hospitalization may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more precise and effective treatments for sepsis, improving patient outcomes.
How similar studies have performed: Previous research has successfully utilized single-cell RNA sequencing to identify immune responses in various conditions, indicating a promising approach for sepsis as well.
Where this research is happening
Boston, United States
- Massachusetts General Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Filbin, Michael — Massachusetts General Hospital
- Study coordinator: Filbin, Michael
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.