How lung cells help TB fight or fail the infection
Official title: Essential Functions of Alveolar Epithelial Cells in Tuberculosis Pathogenesis
Funded at Louisiana State Univ Hsc Shreveport · NIH-11415247 · Data updated 2026-11-12
A research project is studying how alveolar cells in the lungs respond to tuberculosis to uncover new ways to protect lung tissue and reduce damage.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Louisiana State Univ Hsc Shreveport NIH-funded |
| Lab location | 1 site (Shreveport, United States) |
| Project start | August 11, 2026 |
| Project end | July 31, 2031 |
| Funding year | 2026 |
| Award (this year) | $442,500 |
| NIH project number | 1DP2AI200598-01 |
| Project ID | NIH-11415247 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with TB or individuals at risk of TB-related lung damage, especially those with or at risk for alveolar injury.
✕Less likely to help
Very early-stage research; direct patient benefits may not be immediate and require further development.
What this research studies
This project investigates how alveolar epithelial cells, particularly AT2 cells and their progenitors, respond to Mycobacterium tuberculosis infection. Using animal models and cellular systems, the study looks at how TB may disrupt alveolar structure and lung function and whether certain metabolic pathways influence stemness and repair. The goal is to identify mechanisms that could lead to therapies that preserve or restore lung tissue during TB infection. If successful, the work could point to new strategies to prevent long-term lung damage in TB survivors.
Why it matters
Potential benefit: If successful, it could lead to therapies that protect or repair damaged lungs in TB patients.
How similar studies have gone: Preclinical data suggest alveolar epithelium plays a role in TB-related lung damage, but direct human studies are limited.
Where this research is happening
-
Louisiana State Univ Hsc Shreveport
Shreveport, United States Active
Researchers
- Principal investigator: Parveen-Nesson, Sadiya — Louisiana State Univ Hsc Shreveport
- Study coordinator: Parveen-Nesson, Sadiya
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.