Hemostatic B-knob Microgels for Pediatric Bleeding
Official title: Hemostatic B-knob Triggered microGels (Bk-TriGs) that leverage age-dependent clotting mechanisms for treating pediatric trauma associated hemorrhage
Funded at North Carolina State University Raleigh · NIH-11463381 · Data updated 2026-11-12
A kid-friendly hemostatic therapy using age-tuned microgels to stop dangerous bleeding after injury in children.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | North Carolina State University Raleigh NIH-funded |
| Lab location | 1 site (Raleigh, United States) |
| Project start | September 1, 2026 |
| Project end | May 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $698,083 |
| NIH project number | 1R01HL183898-01A1 |
| Project ID | NIH-11463381 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates would be pediatric patients with traumatic bleeding where age-specific coagulation factors are a critical consideration.
✕Less likely to help
Patients with bleeding scenarios not driven by pediatric coagulation differences or those outside the age ranges studied may not benefit.
What this research studies
This project aims to create a new hemostatic treatment that uses age-specific clotting features to control severe bleeding in pediatric trauma patients. Researchers will explore how immature coagulation systems in children respond to the B-knob–triggered microgels and how these materials work with or without standard transfusion practices. The work will combine lab tests and preclinical models to optimize safety and effectiveness for different pediatric age groups, from neonates to adolescents. The ultimate goal is a therapy that can be safely used in real-world pediatric trauma care to reduce the risk of hemorrhagic death.
Why it matters
Potential benefit: If successful, this therapy could reduce mortality from severe bleeding in children after injury and improve outcomes by matching treatment to a child’s developmental stage.
How similar studies have gone: Prior research indicates that age-related differences in coagulation affect transfusion outcomes, and this study builds on that foundation with a novel, targeted hemostatic approach.
Where this research is happening
-
North Carolina State University Raleigh
Raleigh, United States Active
Researchers
- Principal investigator: Brown, Ashley Carson — North Carolina State University Raleigh
- Study coordinator: Brown, Ashley Carson
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.