Hemorrhage and blood vessel health after injury: how red cells and endothelium work together
Official title: Hemorrhage and hemorrheology – the critical interaction of the erythrocyte and the endothelium after injury
Funded at University of Cincinnati · NIH-11375950 · Data updated 2026-11-12
A large NIH grant is exploring how red blood cells and the lining of blood vessels interact after injury to improve bleeding control and outcomes.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Cincinnati NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project start | August 1, 2025 |
| Project end | May 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $405,000 |
| NIH project number | 5R35GM156315-02 |
| Project ID | NIH-11375950 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients who have suffered traumatic injury with bleeding and coagulopathy, or healthy volunteers contributing to mechanistic studies.
✕Less likely to help
Patients without trauma or coagulopathy are unlikely to benefit from this specific research.
What this research studies
This project looks at how trauma-related bleeding and the body’s response involve both red blood cells and the endothelium, with the goal of understanding how fluids and blood products can be used best to restore normal blood flow and clotting. The researchers will study mechanisms of endothelial injury, microcirculation, and how transfused blood components influence hemostasis after trauma. By combining laboratory studies with insights from clinical care, the work aims to guide more effective resuscitation strategies that protect the vascular system. The project is led by investigators at the University of Cincinnati and seeks to translate basic findings into improved treatments for patients who have suffered traumatic injuries.
Why it matters
Potential benefit: If successful, the work could lead to better transfusion strategies and therapies that reduce hemorrhage and improve survival after trauma.
How similar studies have gone: Previous research supports a role for endotheliopathy in trauma; this project builds on known biology and seeks to optimize transfusion to protect the endothelium.
Where this research is happening
-
University of Cincinnati
Cincinnati, United States Active
Researchers
- Principal investigator: Goodman, Michael — University of Cincinnati
- Study coordinator: Goodman, Michael
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.