Fibrinolytic and inflammatory drivers of severe trauma outcomes
Official title: Unraveling the Role of The Fibrinolytic-Inflammatory Axis in Severe Trauma Adverse Outcomes: From Acute Organ Dysfunction to Chronic Disability
Funded at Vanderbilt University Medical Center · NIH-11400058 · Data updated 2026-11-12
This grant looks at how the body's clot-busting system and immune cells interact after severe trauma to influence early organ failure and long-term disability.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project start | September 1, 2025 |
| Project end | June 30, 2029 |
| Funding year | 2026 |
| Award (this year) | $435,510 |
| NIH project number | 5R01GM157158-02 |
| Project ID | NIH-11400058 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are patients who have survived a severe traumatic injury and are at risk for acute organ dysfunction or chronic post-injury symptoms, relevant to future translational work.
✕Less likely to help
Trauma patients who do not experience the inflammatory cascade described or those not proceeding to translation may see minimal direct benefit.
What this research studies
Researchers will study how the fibrinolytic system and innate immune cells like neutrophils and macrophages change after severe trauma in a mouse model. They will use advanced immune cell profiling and tissue analysis to map the sequence of events from early hyperfibrinolysis to late chronic inflammation. The goal is to understand how this progression leads to ongoing organ damage and pain, with the aim of identifying points where treatment could improve recovery.
Why it matters
Potential benefit: If successful, the work could reveal new targets to prevent long-term complications after severe trauma and improve survival and quality of life.
How similar studies have gone: Similar studies in animal models have begun to map immune responses after trauma, but translating these findings to human outcomes remains a key challenge.
Where this research is happening
-
Vanderbilt University Medical Center
Nashville, United States Active
Researchers
- Principal investigator: Schoenecker, Jonathan — Vanderbilt University Medical Center
- Study coordinator: Schoenecker, Jonathan
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.