How where you live shapes midlife disability and thinking skills for low- and high-income adults

Implications of residential location in midlife disability and cognitive functioning among the poor vs. rich: within the US and cross-country comparisons

NIH-funded research University of Michigan at Ann Arbor · NIH-11473589

This project compares how where people live affects disability and thinking skills in middle-aged adults in the US and other high-income countries.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionUniversity of Michigan at Ann Arbor NIH-funded
Lab location1 site (Ann Arbor, United States)
Project IDNIH-11473589 on NIH RePORTER

What this research studies

You will see how researchers compare people with similar personal backgrounds who live in different neighborhoods, counties, and states to find which local features (like services, built environment, and policies) relate to disability and cognitive functioning in midlife. They use residential histories across the life course to measure how long and when people were exposed to different places. The team applies quasi-experimental, multi-level analyses to separate place-level effects from individual circumstances. They also compare US patterns with other high-income countries to understand why working-age adults in the US are falling behind.

Who could benefit from this research

Good fit: Adults aged 21 and older, especially middle-aged people concerned about disability or cognitive changes or able to share detailed residential histories or health survey data, are the best fit.

Not a fit: People seeking direct clinical treatment, children, or anyone without available residential or health records are unlikely to receive personal medical benefit from this research.

Why it matters

Potential benefit: If successful, this work could point to neighborhood, county, or policy changes that reduce midlife disability and cognitive decline and guide local and state actions to improve health.

How similar studies have performed: Prior studies have linked neighborhood and policy environments to health, but combining life-course residential histories with multi-level quasi-experimental and cross-country comparisons is relatively novel.

Where this research is happening

Ann Arbor, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.