Exploring the genetics behind early onset glaucoma
Official title: Using Forward Genetics to Explore the Genetics and Mechanisms of Early Onset Glaucoma
Funded at Ut Southwestern Medical Center · NIH-10889754 · Data updated 2026-11-12
This study is looking at the genes that might cause early onset glaucoma, which can lead to vision loss, by testing mice with random mutations to find out more about the disease and hopefully improve how we screen for it and find new treatments for people affected by it.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project start | July 1, 2024 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $246,000 |
| NIH project number | 1R21EY036238-01 |
| Project ID | NIH-10889754 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with early onset glaucoma or those at risk due to genetic factors.
✕Less likely to help
Patients with late-onset glaucoma or those whose condition is not genetically influenced may not benefit from this research.
What this research studies
This research investigates the genetic factors contributing to early onset glaucoma, a condition that can lead to blindness. By using a Forward Genetics approach, the team aims to identify and characterize the genes and molecular pathways involved in this disease. They will generate random mutations in mice and screen for signs of glaucoma, utilizing a large database of retinal images to find gene associations. The ultimate goal is to improve screening methods and discover new treatment options for patients affected by this condition.
Why it matters
Potential benefit: If successful, this research could lead to better understanding, screening, and treatment options for early onset glaucoma patients.
How similar studies have gone: Previous research using similar genetic approaches has shown promise in identifying genetic causes of other eye diseases, suggesting potential for success in this area as well.
Where this research is happening
-
Ut Southwestern Medical Center
Dallas, United States Active
Researchers
- Principal investigator: Ufret-Vincenty, Rafael — Ut Southwestern Medical Center
- Study coordinator: Ufret-Vincenty, Rafael
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.