Mitochondrial energy problems in men and women with Alzheimer’s disease
Official title: Mitochondrial Energetic Failures in Men and Women Across Trajectories of Alzheimer Disease
Funded at University of Texas Hlth Sci Ctr Houston · NIH-11597696 · Data updated 2026-11-12
This grant tests how mitochondria differ between men and women with Alzheimer's disease to find ways to tailor care.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Sci Ctr Houston NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | September 1, 2026 |
| Project end | August 31, 2031 |
| Funding year | 2026 |
| Award (this year) | $40,824 |
| NIH project number | 3U01AG095419-01S2 |
| Project ID | NIH-11597696 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with Alzheimer’s disease or related dementias who are part of the AMP-AD/ADNI research framework and have consented for biospecimen and imaging studies.
✕Less likely to help
Individuals without Alzheimer’s-related conditions or without consent for research data sharing may not benefit.
What this research studies
Researchers will study how cellular energy in mitochondria relates to brain changes and cognitive symptoms in people with Alzheimer’s and related dementias, using metabolomics, genomic, clinical, and imaging data. The goal is to develop a first bioenergetic capacity index that could help tailor personalized strategies to improve mitochondrial function. The study builds on large, collaborative AMP-AD and ADNI data resources to connect peripheral metabolic signals with brain markers and cognition. Findings could lead to sex-specific approaches for prevention and treatment. The work involves longitudinal data collection and multi-omics integration to understand disease trajectories.
Why it matters
Potential benefit: If successful, patients could benefit from personalized strategies that target mitochondrial energy and metabolism to slow or modify disease progression.
How similar studies have gone: Prior multi-omics studies have shown links between metabolism and brain changes in AD, supporting further exploration of this approach.
Where this research is happening
-
University of Texas Hlth Sci Ctr Houston
Houston, United States Active
Researchers
- Principal investigator: Kaddurah-Daouk, Rima F — University of Texas Hlth Sci Ctr Houston
- Study coordinator: Kaddurah-Daouk, Rima F
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.