Understanding Alzheimer's Genetic Risk in African and Admixed African-American People
Official title: Characterizing the Genetic Risk for Alzheimer Disease in African and Admixed African-American Ancestries
Funded at University of Miami School of Medicine · NIH-11595891 · Data updated 2026-11-12
A study looks at genetic factors and biomarkers to understand why Alzheimer's disease affects African and admixed African-American communities differently.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Miami School of Medicine NIH-funded |
| Lab location | 1 site (Coral Gables, United States) |
| Project start | September 30, 2024 |
| Project end | August 31, 2029 |
| Funding year | 2026 |
| Award (this year) | $66,614 |
| NIH project number | 3U01AG084545-03S9 |
| Project ID | NIH-11595891 on NIH RePORTER |
Who could benefit from this research
✓Could help
Individuals of African or admixed African-American ancestry, with or without cognitive impairment, who may participate in genetic, biomarker, imaging, and follow-up assessments.
✕Less likely to help
Persons outside the target ancestry groups or those not within the study’s recruitment/retention framework may not directly benefit.
What this research studies
Researchers will collect DNA, blood biomarkers, and MRI data from about 9,000 individuals of African ancestry, along with long-term follow-up to track cognitive changes. The project builds on existing cohorts and adds new participants to explore how genetics and biomarkers relate to Alzheimer's risk across diverse populations. It aims to create a richer picture of who is at risk and how the disease progresses in these groups, which could guide more inclusive prevention and treatment strategies.
Why it matters
Potential benefit: This research could lead to more accurate risk prediction and personalized approaches for preventing or delaying Alzheimer's in African and admixed populations.
How similar studies have gone: Prior studies show genetic and biomarker differences across ancestries, supporting the potential value of this diverse approach.
Where this research is happening
-
University of Miami School of Medicine
Coral Gables, United States Active
Researchers
- Principal investigator: Griswold, Anthony John — University of Miami School of Medicine
- Study coordinator: Griswold, Anthony John
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.