Mitochondrial energy problems in people with Alzheimer’s and related brain diseases
Official title: Mitochondrial Energetic Failures in Men and Women Across Trajectories of Alzheimer Disease
Funded at University of Texas Hlth Sci Ctr Houston · NIH-11597686 · Data updated 2026-11-12
A research effort is looking at how mitochondrial energy problems differ between men and women with Alzheimer’s disease and related dementias and what this means for future care.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Sci Ctr Houston NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | September 1, 2026 |
| Project end | August 31, 2031 |
| Funding year | 2026 |
| Award (this year) | $178,136 |
| NIH project number | 3U01AG095419-01S1 |
| Project ID | NIH-11597686 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults diagnosed with Alzheimer’s disease or related dementias who are willing to participate in multi-omics and imaging studies.
✕Less likely to help
Patients who do not meet the study’s specific biomarker, imaging, or consent requirements may not benefit from this research.
What this research studies
This project studies how energy production in mitochondria is linked to brain changes and symptoms in people with Alzheimer’s disease and related dementias, using data from genetics, metabolism, imaging, and clinical assessments. By focusing on sex-specific differences, researchers hope to identify metabolic patterns that could guide personalized approaches in treatment or prevention. The work leverages large, collaborative data resources to connect peripheral metabolic signals with brain pathology and cognitive outcomes. The aim is to develop a bioenergetic index that could help tailor interventions to individual patients.
Why it matters
Potential benefit: If successful, the research could enable more personalized strategies to maintain mitochondrial energy in patients and potentially slow disease progression.
How similar studies have gone: Previous multi-omics studies have linked metabolic changes to brain and cognitive changes, with the potential for personalized approaches, but sex-specific differences require further validation.
Where this research is happening
-
University of Texas Hlth Sci Ctr Houston
Houston, United States Active
Researchers
- Principal investigator: Kaddurah-Daouk, Rima F — University of Texas Hlth Sci Ctr Houston
- Study coordinator: Kaddurah-Daouk, Rima F
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.