How high altitude affects blood vessel function in mothers and their babies during pregnancy
Gestational Hypoxia and Programming of Maternal, Fetal and Newborn Vascular Function
['FUNDING_R01'] · LOMA LINDA UNIVERSITY · NIH-10650166
This study looks at how living at high altitudes with low oxygen affects the blood vessels of pregnant women and their babies, aiming to find out how these changes can lead to complications like preeclampsia and growth issues, so we can better support pregnancies in those conditions.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | LOMA LINDA UNIVERSITY (nih funded) |
| Locations | 1 site (Loma Linda, UNITED STATES) |
| Trial ID | NIH-10650166 on ClinicalTrials.gov |
What this research studies
This research investigates how long-term exposure to low oxygen levels at high altitudes impacts the blood vessel function of mothers, fetuses, and newborns. It focuses on understanding the cellular and molecular changes that occur in response to gestational hypoxia, which can lead to serious complications such as preeclampsia and intrauterine growth restriction (IUGR). By studying both human and animal models, the research aims to uncover the mechanisms behind these adaptations and their effects on health outcomes. Patients may benefit from insights that could lead to improved management of pregnancies affected by high altitude conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research include pregnant women living at high altitudes or those experiencing complications related to low oxygen levels during pregnancy.
Not a fit: Patients who are not pregnant or those living at sea level may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to better strategies for managing pregnancies at high altitudes, potentially reducing risks for mothers and their babies.
How similar studies have performed: Previous research has shown significant impacts of hypoxia on vascular function, indicating that this approach is grounded in established findings.
Where this research is happening
Loma Linda, UNITED STATES
- LOMA LINDA UNIVERSITY — Loma Linda, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ZHANG, LUBO — LOMA LINDA UNIVERSITY
- Study coordinator: ZHANG, LUBO
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.