Diabetes development after acute pancreatitis: factors, beta cell health, and immune clues
Official title: Clinical, Radiologic and Biochemical Factors Related to Diabetes Development after Acute Pancreatitis
Funded at Johns Hopkins University · NIH-11413528 · Data updated 2026-11-12
This project follows people who had acute pancreatitis to see who develops diabetes, why it happens, and how beta cells and the immune system are involved.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | September 16, 2020 |
| Project end | July 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $473,000 |
| NIH project number | 5U01DK127400-07 |
| Project ID | NIH-11413528 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults who have experienced acute pancreatitis and are being followed in the DREAM and IMMINENT ancillary studies, with interest in diabetes risk after pancreatitis.
✕Less likely to help
People who have not had acute pancreatitis or who are not enrolled in the DREAM/IMMINENT studies may not directly benefit.
What this research studies
If you’ve had acute pancreatitis, this study looks at who goes on to develop diabetes and what clues (like blood markers and immune signals) predict that risk. The team is tracking participants over time, collecting clinical data, imaging, and lab tests to understand beta cell function and immune responses after pancreatitis. They also plan new analyses of autoantigens and signatures that could reveal why diabetes emerges in some patients. This work builds on ongoing cohorts at Johns Hopkins to improve prediction, early detection, and potential intervention for post-pancreatitis diabetes.
Why it matters
Potential benefit: Better understanding of risk factors could lead to earlier monitoring and personalized care for people after pancreatitis who may develop diabetes.
How similar studies have gone: Prior work shows variability in post-pancreatitis diabetes risk; this program aims to clarify mechanisms and improve prediction in a large longitudinal setup.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Singh, Vikesh — Johns Hopkins University
- Study coordinator: Singh, Vikesh
Related research
Other NIH-funded projects on the same topics.
-
Diabetes after acute pancreatitis: understanding and tracking progression
A patient-focused look at how diabetes can develop after an episode of acute pancreatitis, using data from a large, ongoing study and AI insights.
-
Continuation of Type 1 Diabetes in Acute Pancreatitis: UF Health and AdventHealth
A patient-facing overview of a long-term study tracking people with acute pancreatitis to understand how some develop type 1 diabetes later and what factors influence that process.
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Data Coordinating Center for Type 1 Diabetes in Acute Pancreatitis Consortium
A national effort to learn how pancreatitis-related Type 1 diabetes develops, by tracking patients and coordinating data to improve future care.
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Diabetes after acute pancreatitis: a patient-focused network study
A program at Indiana University is studying how diabetes can develop after an acute pancreatitis episode, with new findings that could help doctors tailor care for adults who had pancreatitis.
-
Type 1 Diabetes in Acute Pancreatitis in Diabetes Patients at Stanford
A Stanford-led project helps people with brittle type 1 diabetes who also experience pancreatitis by following them in a long-term study to understand how acute pancreatitis affects diabetes.
-
Epidemiology and causes of diabetes after acute pancreatitis
A long-term study following people who have had acute pancreatitis to understand how often diabetes develops, why it happens, and how it progresses.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.