CORVETS: Tracking Flu, COVID-19, and other Respiratory Virus Vaccine Effectiveness in Cleveland
Official title: RFA-IP-22-004, CORVETS - Cleveland Ohio Respiratory Viruses Vaccines Effectiveness across Traditional Risk Factors and Social Determinants of Health
Funded at University Hospitals of Cleveland · NIH-11383273 · Data updated 2026-11-12
A Cleveland-based effort will study how well flu, COVID-19, and other respiratory virus vaccines work in real-life patients across diverse communities.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University Hospitals of Cleveland NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project start | September 30, 2022 |
| Project end | September 29, 2027 |
| Funding year | 2026 |
| Award (this year) | $1,050,000 |
| NIH project number | 5U01IP001181-05 |
| Project ID | NIH-11383273 on NIH RePORTER |
Who could benefit from this research
✓Could help
Individuals of any age with medically attended acute respiratory illness presenting in ambulatory settings in the Cleveland area who are willing to share health information and biospecimen data.
✕Less likely to help
Participants who do not experience vaccine-preventable illness or who choose not to participate may see no direct benefit.
What this research studies
This project will enroll at least 1,000 patients per year who have medically attended respiratory illnesses in ambulatory clinics and create a digital biorepository with vaccine and health data. Researchers will use advanced testing, including viral genome sequencing, to understand which viruses are present and how vaccines perform against them. They will examine personal and household factors that influence vaccine effectiveness and illness risk, using data from diverse participants. The work is done in collaboration with Case Western Reserve University and the Louis Stokes Cleveland VA Medical Center, and it will build a platform for measuring vaccine impact in real-world settings.
Why it matters
Potential benefit: If successful, the project could improve understanding of who benefits most from vaccines and how to tailor vaccination strategies in diverse communities.
How similar studies have gone: Previous platforms have shown that real-world vaccine effectiveness can vary by population and variant, guiding better vaccination policies.
Where this research is happening
-
University Hospitals of Cleveland
Cleveland, United States Active
Researchers
- Principal investigator: Saade, Elie — University Hospitals of Cleveland
- Study coordinator: Saade, Elie
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.