Comparing two methods of glaucoma drainage device placement
Official title: Glaucoma Drainage Device and Endothelial Cell Density Loss Compare (DECLARE) Trial
Funded at University of California, San Francisco · NIH-11074588 · Data updated 2026-11-12
This study is looking at how the placement of glaucoma drainage devices affects eye health, specifically focusing on which method helps keep your eye pressure stable while causing less harm to the cells in your cornea, and it's for people with glaucoma who might need this type of surgery.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | April 1, 2023 |
| Project end | March 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $1,038,103 |
| NIH project number | 5UG1EY033703-03 |
| Project ID | NIH-11074588 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with medically uncontrolled glaucoma who are considering glaucoma drainage device surgery.
✕Less likely to help
Patients with well-controlled glaucoma or those who are not candidates for surgical intervention may not benefit from this research.
What this research studies
This research investigates the effects of two different placements of glaucoma drainage devices (GDD) on corneal endothelial cell loss and other surgical outcomes. Patients will be randomly assigned to receive either a tube placed in the anterior chamber or in the ciliary sulcus. The study aims to determine which placement method results in better control of intraocular pressure and minimizes damage to the corneal cells. By analyzing data from 240 participants across multiple centers, the research seeks to provide clearer guidance on the optimal surgical technique for managing glaucoma.
Why it matters
Potential benefit: If successful, this research could lead to improved surgical techniques that preserve corneal health and enhance the quality of life for glaucoma patients.
How similar studies have gone: Previous studies have shown mixed results regarding the outcomes of different GDD placements, indicating that this research could provide valuable new insights.
Where this research is happening
-
University of California, San Francisco
San Francisco, United States Active
Researchers
- Principal investigator: Han, Ying — University of California, San Francisco
- Study coordinator: Han, Ying
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.