Effects of therapy and medication on sleep and blood pressure in people with insomnia
1/2 Cognitive Behavioral Therapy and Trazodone Effects on Sleep and Blood Pressure in Insomnia Phenotypes Based on Objective Sleep Duration: A Sequential Cohort/Randomized Controlled Trial
This study is looking at how two different treatments—Cognitive Behavioral Therapy for Insomnia (CBT-I) and the medication trazodone—can help improve sleep quality and lower blood pressure in adults who struggle with insomnia, especially those who don’t get enough sleep.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Pennsylvania State Univ Hershey Med Ctr NIH-funded |
| Lab location | 1 site (Hershey, United States) |
| Project ID | NIH-10951138 on NIH RePORTER |
What this research studies
This research investigates how Cognitive Behavioral Therapy for Insomnia (CBT-I) and the medication trazodone affect sleep quality and blood pressure in adults with different types of insomnia. It focuses on individuals with insomnia characterized by short sleep duration, which is linked to higher health risks. The study will involve a cohort of 600 adults, assessing the effectiveness of CBT-I compared to trazodone, particularly for those who do not respond to CBT-I. Participants will be monitored for changes in sleep duration, blood pressure, and cortisol levels.
Who could benefit from this research
Good fit: Ideal candidates are adults aged 21 and older who experience insomnia, particularly those with short sleep duration and elevated blood pressure.
Not a fit: Patients who do not have insomnia or those whose insomnia is not characterized by short sleep duration may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options for insomnia that also help lower blood pressure and reduce health risks.
How similar studies have performed: Previous research has shown promising results for CBT-I and trazodone in treating insomnia, but this specific approach focusing on insomnia phenotypes is relatively novel.
Where this research is happening
Hershey, United States
- Pennsylvania State Univ Hershey Med Ctr — Hershey, United States (Active)
Researchers
- Principal investigator: Vgontzas, Alexandros N — Pennsylvania State Univ Hershey Med Ctr
- Study coordinator: Vgontzas, Alexandros N
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.