Clozapine to prevent violent behavior in people with schizophrenia
Official title: 5/7 Clozapine for the Prevention of Violence in Schizophrenia: a Randomized Clinical Trial
Funded at Nathan S. Kline Institute for Psych Res · NIH-11134582 · Data updated 2026-11-12
This project compares clozapine to usual care to find out whether clozapine lowers the chance of violent acts in people with schizophrenia who are at higher risk.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Nathan S. Kline Institute for Psych Res NIH-funded |
| Lab location | 1 site (Orangeburg, United States) |
| Project start | July 1, 2021 |
| Project end | June 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $203,625 |
| NIH project number | 5R01MH120185-05 |
| Project ID | NIH-11134582 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with schizophrenia who are judged to be at high risk for violent acts and who can take clozapine with required blood monitoring would be ideal candidates.
✕Less likely to help
People without schizophrenia, those not at elevated risk for violence, or anyone with medical reasons that prevent clozapine use (such as a history of serious blood disorders or inability to undergo regular blood tests) may not benefit.
What this research studies
If you have schizophrenia and are considered at high risk for violent behavior, the trial would randomly assign you to take clozapine or to continue usual treatment for 24 weeks. The trial runs at seven sites and plans to enroll 280 people from community outpatient settings, coordinated by the New York State Psychiatric Institute. It is open-label (you and your doctors know the treatment) but the person who rates outcomes is blind, and the main measure is the time until a violent act occurs. The team will track safety, behavior, and other clinical outcomes during the 24-week period.
Why it matters
Potential benefit: If successful, this could reduce violent behavior and related harms for people with schizophrenia and improve safety and community functioning.
How similar studies have gone: Previous smaller and mostly observational studies suggest clozapine can reduce aggression, but a large randomized community-based trial has not yet confirmed this effect.
Where this research is happening
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Nathan S. Kline Institute for Psych Res
Orangeburg, United States Active
Researchers
- Principal investigator: Lindenmayer, Jean-Pierre — Nathan S. Kline Institute for Psych Res
- Study coordinator: Lindenmayer, Jean-Pierre
Related research
Other NIH-funded projects on the same topics.
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Clozapine to reduce violence in schizophrenia
A large study will compare clozapine to usual treatment to see if it lowers violent acts in people with schizophrenia who are at high risk of violence.
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Clozapine to reduce violent behavior in people with schizophrenia
This compares clozapine with usual care to try to lower the chance of violent acts in people with schizophrenia who are at higher risk.
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Clozapine to Help Prevent Violence in Schizophrenia
This project looks at whether a medication called clozapine can help people with schizophrenia reduce violent behavior.
-
Clozapine to prevent violence in schizophrenia
This project explores if a medication called clozapine can help reduce violent behavior in people living with schizophrenia.
-
Clozapine to reduce violence in people with schizophrenia
This trial will compare clozapine with usual antipsychotic care to see whether clozapine lowers the chance of violent acts in people with schizophrenia who are at high risk.
-
Clozapine to prevent violent behavior in people with schizophrenia
This trial will compare clozapine with usual treatment to see if it lowers the chance of violent acts in people with schizophrenia who are at high risk.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.