Clozapine to Help Prevent Violence in Schizophrenia
Official title: 7/7 Clozapine for the Prevention of Violence in Schizophrenia: a Randomized Clinical Trial
Funded at Augusta University · NIH-11135385 · Data updated 2026-11-12
This project looks at whether a medication called clozapine can help people with schizophrenia reduce violent behavior.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Augusta University NIH-funded |
| Lab location | 1 site (Augusta, United States) |
| Project start | July 1, 2021 |
| Project end | June 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $192,500 |
| NIH project number | 5R01MH120316-05 |
| Project ID | NIH-11135385 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are individuals with schizophrenia who are considered to be at high risk for violent acts.
✕Less likely to help
Patients who do not have schizophrenia or are not at risk for violent behavior would likely not benefit from this specific approach.
What this research studies
Many people with schizophrenia are not violent, but some may be at higher risk, which can lead to worse health and more stigma. We are conducting a large, multi-site study to see if clozapine, a medication already used for schizophrenia, can effectively lower the risk of violent acts. Participants will be randomly assigned to either receive clozapine or their usual treatment for 24 weeks. Our goal is to understand if clozapine can make a meaningful difference in preventing violence in community settings.
Why it matters
Potential benefit: If successful, this work could offer a new way to help people with schizophrenia manage their condition and reduce the risk of violent behavior, improving their lives and reducing stigma.
How similar studies have gone: Previous smaller or observational studies have suggested clozapine's effectiveness, but this will be the first large, randomized study specifically focused on preventing violent acts in community settings.
Where this research is happening
-
Augusta University
Augusta, United States Active
Researchers
- Principal investigator: Mcevoy, Joseph Patrick — Augusta University
- Study coordinator: Mcevoy, Joseph Patrick
Related research
Other NIH-funded projects on the same topics.
-
Clozapine to reduce violence in schizophrenia
A large study will compare clozapine to usual treatment to see if it lowers violent acts in people with schizophrenia who are at high risk of violence.
-
Clozapine to reduce violent behavior in people with schizophrenia
This compares clozapine with usual care to try to lower the chance of violent acts in people with schizophrenia who are at higher risk.
-
Clozapine to prevent violence in schizophrenia
This project explores if a medication called clozapine can help reduce violent behavior in people living with schizophrenia.
-
Clozapine to reduce violence in people with schizophrenia
This trial will compare clozapine with usual antipsychotic care to see whether clozapine lowers the chance of violent acts in people with schizophrenia who are at high risk.
-
Clozapine to prevent violent behavior in people with schizophrenia
This trial will compare clozapine with usual treatment to see if it lowers the chance of violent acts in people with schizophrenia who are at high risk.
-
Clozapine to prevent violent behavior in people with schizophrenia
This project compares clozapine to usual care to find out whether clozapine lowers the chance of violent acts in people with schizophrenia who are at higher risk.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.