Clozapine to Help Prevent Violence in Schizophrenia
7/7 Clozapine for the Prevention of Violence in Schizophrenia: a Randomized Clinical Trial
This project looks at whether a medication called clozapine can help people with schizophrenia reduce violent behavior.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Augusta University NIH-funded |
| Lab location | 1 site (Augusta, United States) |
| Project ID | NIH-11135385 on NIH RePORTER |
What this research studies
Many people with schizophrenia are not violent, but some may be at higher risk, which can lead to worse health and more stigma. We are conducting a large, multi-site study to see if clozapine, a medication already used for schizophrenia, can effectively lower the risk of violent acts. Participants will be randomly assigned to either receive clozapine or their usual treatment for 24 weeks. Our goal is to understand if clozapine can make a meaningful difference in preventing violence in community settings.
Who could benefit from this research
Good fit: Ideal candidates are individuals with schizophrenia who are considered to be at high risk for violent acts.
Not a fit: Patients who do not have schizophrenia or are not at risk for violent behavior would likely not benefit from this specific approach.
Why it matters
Potential benefit: If successful, this work could offer a new way to help people with schizophrenia manage their condition and reduce the risk of violent behavior, improving their lives and reducing stigma.
How similar studies have performed: Previous smaller or observational studies have suggested clozapine's effectiveness, but this will be the first large, randomized study specifically focused on preventing violent acts in community settings.
Where this research is happening
Augusta, United States
- Augusta University — Augusta, United States (Active)
Researchers
- Principal investigator: Mcevoy, Joseph Patrick — Augusta University
- Study coordinator: Mcevoy, Joseph Patrick
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.