Clozapine to prevent violence in schizophrenia
Official title: 3/7 Clozapine for the Prevention of Violence in Schizophrenia: A Randomized Clinical Trial
Funded at Univ of North Carolina Chapel Hill · NIH-11134680 · Data updated 2026-11-12
This project explores if a medication called clozapine can help reduce violent behavior in people living with schizophrenia.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of North Carolina Chapel Hill NIH-funded |
| Lab location | 1 site (Chapel Hill, United States) |
| Project start | July 1, 2021 |
| Project end | June 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $194,375 |
| NIH project number | 5R01MH120253-05 |
| Project ID | NIH-11134680 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are individuals diagnosed with schizophrenia who are identified as being at high risk for violent behavior.
✕Less likely to help
Patients who do not have schizophrenia or are not at risk for violent behavior would not directly benefit from this specific research.
What this research studies
While most people with psychosis are not dangerous, some individuals with psychotic disorders face an increased risk for violence, which can lead to worse outcomes and increased stigma. We are conducting a large, multi-site clinical comparison to see if clozapine, an existing antipsychotic medication, is better than usual care at preventing violent acts. Participants will be randomly assigned to receive either clozapine or their standard treatment for 24 weeks. Our aim is to provide clear evidence on clozapine's effectiveness in reducing violence for individuals with schizophrenia in community settings.
Why it matters
Potential benefit: If successful, this could provide a proven treatment option to significantly reduce violent behavior in individuals with schizophrenia, improving their safety and quality of life.
How similar studies have gone: Previous smaller studies have suggested clozapine's potential, but this project is a large, randomized comparison designed to provide more definitive evidence in real-world settings.
Where this research is happening
-
Univ of North Carolina Chapel Hill
Chapel Hill, United States Active
Researchers
- Principal investigator: Jarskog, Lars Fredrik — Univ of North Carolina Chapel Hill
- Study coordinator: Jarskog, Lars Fredrik
Related research
Other NIH-funded projects on the same topics.
-
Clozapine to reduce violence in schizophrenia
A large study will compare clozapine to usual treatment to see if it lowers violent acts in people with schizophrenia who are at high risk of violence.
-
Clozapine to reduce violent behavior in people with schizophrenia
This compares clozapine with usual care to try to lower the chance of violent acts in people with schizophrenia who are at higher risk.
-
Clozapine to Help Prevent Violence in Schizophrenia
This project looks at whether a medication called clozapine can help people with schizophrenia reduce violent behavior.
-
Clozapine to reduce violence in people with schizophrenia
This trial will compare clozapine with usual antipsychotic care to see whether clozapine lowers the chance of violent acts in people with schizophrenia who are at high risk.
-
Clozapine to prevent violent behavior in people with schizophrenia
This trial will compare clozapine with usual treatment to see if it lowers the chance of violent acts in people with schizophrenia who are at high risk.
-
Clozapine to prevent violent behavior in people with schizophrenia
This project compares clozapine to usual care to find out whether clozapine lowers the chance of violent acts in people with schizophrenia who are at higher risk.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.