Clozapine to prevent violent behavior in people with schizophrenia
Official title: 2/7 Clozapine for the Prevention of Violence in Schizophrenia: a Randomized Clinical Trial
Funded at New York University School of Medicine · NIH-11134600 · Data updated 2026-11-12
This trial will compare clozapine with usual treatment to see if it lowers the chance of violent acts in people with schizophrenia who are at high risk.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | July 1, 2021 |
| Project end | June 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $254,250 |
| NIH project number | 5R01MH120318-05 |
| Project ID | NIH-11134600 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with schizophrenia who are considered at high risk for violent behavior and who can comply with clozapine’s medical monitoring would be ideal candidates.
✕Less likely to help
People without schizophrenia, those at low risk for violence, or those who cannot tolerate clozapine or meet its monitoring requirements may not receive benefit from this trial.
What this research studies
If you join, you would be randomly assigned to take clozapine or to continue usual antipsychotic care for 24 weeks. The trial is open-label (you and your doctors will know the medication) and a blinded rater will track outcomes at regular visits. About 280 adults at seven U.S. sites will be enrolled, and the main outcome is time until a violent act occurs. The study is coordinated by the New York State Psychiatric Institute and includes regular safety monitoring required for clozapine.
Why it matters
Potential benefit: If successful, this could show clozapine reduces violent behavior and improve safety and quality of life for people with schizophrenia.
How similar studies have gone: Smaller or observational studies suggest clozapine can reduce aggression, but no large randomized community trial has definitively proven this effect.
Where this research is happening
-
New York University School of Medicine
New York, United States Active
Researchers
- Principal investigator: Goff, Donald C. — New York University School of Medicine
- Study coordinator: Goff, Donald C.
Related research
Other NIH-funded projects on the same topics.
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Clozapine to reduce violence in schizophrenia
A large study will compare clozapine to usual treatment to see if it lowers violent acts in people with schizophrenia who are at high risk of violence.
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Clozapine to reduce violent behavior in people with schizophrenia
This compares clozapine with usual care to try to lower the chance of violent acts in people with schizophrenia who are at higher risk.
-
Clozapine to Help Prevent Violence in Schizophrenia
This project looks at whether a medication called clozapine can help people with schizophrenia reduce violent behavior.
-
Clozapine to prevent violence in schizophrenia
This project explores if a medication called clozapine can help reduce violent behavior in people living with schizophrenia.
-
Clozapine to reduce violence in people with schizophrenia
This trial will compare clozapine with usual antipsychotic care to see whether clozapine lowers the chance of violent acts in people with schizophrenia who are at high risk.
-
Clozapine to prevent violent behavior in people with schizophrenia
This project compares clozapine to usual care to find out whether clozapine lowers the chance of violent acts in people with schizophrenia who are at higher risk.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.