Understanding how blood pressure medicine during pregnancy affects children's development and growth
Official title: Offspring Neurodevelopment and Growth after Early Antihypertensive Therapy OR Preeclampsia in Women with Chronic Hypertension and Pregnancy (CHAP Child).
Funded at University of Alabama at Birmingham · NIH-11097227 · Data updated 2026-11-12
This project looks at how blood pressure medication taken by mothers during pregnancy, or developing preeclampsia, might affect their children's brain development and growth as they get older.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Alabama at Birmingham NIH-funded |
| Lab location | 1 site (Birmingham, United States) |
| Project start | September 20, 2023 |
| Project end | May 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $1,485,190 |
| NIH project number | 5R01HD112994-03 |
| Project ID | NIH-11097227 on NIH RePORTER |
Who could benefit from this research
✓Could help
Children who were born to mothers who participated in the original CHAP trial are the focus of this follow-up.
✕Less likely to help
Individuals who were not part of the original CHAP trial or who are not children of participants would not directly benefit from this specific follow-up.
What this research studies
The original CHAP trial showed that treating mild chronic high blood pressure during pregnancy improved outcomes for mothers and babies. Now, we want to understand the long-term effects of this treatment on the children who were part of that trial. We are also looking at how preeclampsia, a serious pregnancy complication, might impact a child's development and growth over time. Our goal is to see if these factors influence things like brain development, overall growth, and future health risks like weight and blood pressure in childhood.
Why it matters
Potential benefit: If successful, this work could help doctors better understand the long-term safety of blood pressure medications during pregnancy and the impact of preeclampsia on children, guiding future care for pregnant individuals and their offspring.
How similar studies have gone: The original CHAP trial successfully demonstrated benefits of treating chronic hypertension in pregnancy, and this project builds directly on that established cohort to answer new, critical questions.
Where this research is happening
-
University of Alabama at Birmingham
Birmingham, United States Active
Researchers
- Principal investigator: Tita, Alan Thevenet N. — University of Alabama at Birmingham
- Study coordinator: Tita, Alan Thevenet N.
Related research
Other NIH-funded projects on the same topics.
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Children's long-term health after treating chronic hypertension in pregnancy
This grant studies how giving antihypertensive medicine during pregnancy for women with chronic high blood pressure affects their children’s health as they grow up.
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How treating mild high blood pressure in pregnancy affects women's long-term heart health
This project looks at whether taking blood pressure medicine during pregnancy and developing superimposed preeclampsia change long-term heart and health outcomes for women who had mild chronic high blood pressure while pregnant.
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Ethical, multimodal AI for predicting preeclampsia risk in early pregnancy
A data-driven AI tool uses early-pregnancy information from medical records, ultrasound, and notes to predict preeclampsia risk and support safer pregnancy care.
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Dynamic risk prediction and subtyping of hypertensive disorders in pregnancy
A digital health approach uses AI to spot early warning signs of preeclampsia and gestational hypertension from pregnancy data, so clinicians can tailor care for pregnant people.
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Multilevel, patient-centered plan to prevent high blood pressure in pregnancy
A multilevel, patient-centered plan aims to help high-risk pregnant people prevent hypertension during pregnancy using aspirin, BP monitoring, and community support.
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Understanding how genes and environment interact to cause preeclampsia and later high blood pressure in mothers
This project looks at why some pregnancies develop preeclampsia and how it relates to long-term blood pressure and heart health in mothers.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.