Understanding how blood pressure medicine during pregnancy affects children's development and growth
Offspring Neurodevelopment and Growth after Early Antihypertensive Therapy OR Preeclampsia in Women with Chronic Hypertension and Pregnancy (CHAP Child).
This project looks at how blood pressure medication taken by mothers during pregnancy, or developing preeclampsia, might affect their children's brain development and growth as they get older.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Alabama at Birmingham NIH-funded |
| Lab location | 1 site (Birmingham, United States) |
| Project ID | NIH-11097227 on NIH RePORTER |
What this research studies
The original CHAP trial showed that treating mild chronic high blood pressure during pregnancy improved outcomes for mothers and babies. Now, we want to understand the long-term effects of this treatment on the children who were part of that trial. We are also looking at how preeclampsia, a serious pregnancy complication, might impact a child's development and growth over time. Our goal is to see if these factors influence things like brain development, overall growth, and future health risks like weight and blood pressure in childhood.
Who could benefit from this research
Good fit: Children who were born to mothers who participated in the original CHAP trial are the focus of this follow-up.
Not a fit: Individuals who were not part of the original CHAP trial or who are not children of participants would not directly benefit from this specific follow-up.
Why it matters
Potential benefit: If successful, this work could help doctors better understand the long-term safety of blood pressure medications during pregnancy and the impact of preeclampsia on children, guiding future care for pregnant individuals and their offspring.
How similar studies have performed: The original CHAP trial successfully demonstrated benefits of treating chronic hypertension in pregnancy, and this project builds directly on that established cohort to answer new, critical questions.
Where this research is happening
Birmingham, United States
- University of Alabama at Birmingham — Birmingham, United States (Active)
Researchers
- Principal investigator: Tita, Alan Thevenet N. — University of Alabama at Birmingham
- Study coordinator: Tita, Alan Thevenet N.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.