How treating mild high blood pressure in pregnancy affects women's long-term heart health
Pregnancy as a Window to the Future: Outcomes of Antihypertensive Therapy and Superimposed Preeclampsia in Pregnant Women with Mild Chronic Hypertension (CHAP Maternal Follow-up Study)
This project looks at whether taking blood pressure medicine during pregnancy and developing superimposed preeclampsia change long-term heart and health outcomes for women who had mild chronic high blood pressure while pregnant.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Alabama at Birmingham NIH-funded |
| Lab location | 1 site (Birmingham, United States) |
| Project ID | NIH-11171373 on NIH RePORTER |
What this research studies
This follow-up tracks women who took part in the CHAP trial to see how their health fared years after their pregnancy. Researchers will compare long-term outcomes like heart disease, stroke, and metabolic conditions in women who used antihypertensive drugs early in pregnancy versus those who did not, and in women who developed superimposed preeclampsia versus those who did not. Data will come from clinic visits, medical records, questionnaires, and routine lab or health measures collected during follow-up. The goal is to clarify whether pregnancy treatment choices and pregnancy complications affect future cardiovascular risk so clinicians can give better advice.
Who could benefit from this research
Good fit: Ideal candidates are women who had mild chronic high blood pressure during pregnancy and especially those who were enrolled in the original CHAP trial.
Not a fit: People without a history of chronic hypertension during pregnancy, men, or those not part of the CHAP follow-up are unlikely to receive direct benefit from this project.
Why it matters
Potential benefit: If successful, the results could help doctors and patients make clearer choices about blood pressure treatment during pregnancy to lower future heart disease risk.
How similar studies have performed: The original CHAP randomized trial showed short-term benefits and safety of treating mild chronic hypertension during pregnancy, but long-term impacts remain largely untested and this follow-up is novel.
Where this research is happening
Birmingham, United States
- University of Alabama at Birmingham — Birmingham, United States (Active)
Researchers
- Principal investigator: Tita, Alan Thevenet N. — University of Alabama at Birmingham
- Study coordinator: Tita, Alan Thevenet N.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.