Alzheimer’s risk factors in Black adults living with HIV
Official title: A multidisciplinary study of Alzheimer's disease risk factors in Blacks/African Americans living with HIV
Funded at Georgetown University · NIH-11382938 · Data updated 2026-11-12
A five-year study to understand how genetic risk for Alzheimer's disease affects brain function in older Black Americans living with HIV.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Georgetown University NIH-funded |
| Lab location | 1 site (Washington, United States) |
| Project start | August 1, 2025 |
| Project end | April 30, 2030 |
| Funding year | 2026 |
| Award (this year) | $775,352 |
| NIH project number | 5R01AG089864-02 |
| Project ID | NIH-11382938 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are aging HIV-positive Black/African American adults who may carry Alzheimer’s risk genes (notably APOE ε4).
✕Less likely to help
Individuals without HIV or those not willing to provide genetic or brain health information may have less direct benefit.
What this research studies
This project will follow a diverse group of HIV-positive Black adults to look at how genes linked to Alzheimer's risk, especially APOE ε4, relate to brain health over time. Researchers will combine cross-sectional and long-term observations to build a clearer picture of who is most at risk and how risk factors evolve. The study uses existing cohorts and observational methods to gather data on brain function, cognition, and genetics. Findings could help tailor prevention and care for people who live with both HIV and higher Alzheimer's risk.
Why it matters
Potential benefit: If successful, the work could inform personalized strategies to reduce dementia risk and improve brain health for HIV-positive Black adults.
How similar studies have gone: Previous research shows that combining genetic risk data with brain imaging can reveal associations with cognitive outcomes, but this study focuses on a high-risk population that has been understudied.
Where this research is happening
-
Georgetown University
Washington, United States Active
Researchers
- Principal investigator: Jiang, Xiong — Georgetown University
- Study coordinator: Jiang, Xiong
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.