Condition

T2DM clinical trials and research

• 10Clinical trials
• 12NIH research projects
• 4Countries

Newest T2DM clinical trials

All recruiting trials (10)

• HRS9531 tablets for adults with type 2 diabetes not controlled by lifestyle or metformin

  This trial tests whether HRS9531 tablets help people with type 2 diabetes who have not reached their blood sugar goals on lifestyle changes or on metformin alone.

  Recruiting at 2 sites Phase 2 Fujian Shengdi Pharmaceutical Co., Ltd. · Beijing, Beijing Municipality and 1 other locations · NCT07599410

• HM15275 in adults with type 2 diabetes who have not yet reached goal

  This phase 2 trial tests HM15275 or a placebo to see if it helps adults with type 2 diabetes improve blood sugar over 36 weeks.

  Recruiting at 20 sites Phase 2 Hanmi Pharmaceutical Company Limited · Mesa, Arizona and 19 other locations · NCT07527650

• HTD1801 vs placebo for kidney protection in type 2 diabetes and CKD

  This trial tests whether HTD1801 can slow kidney decline in adults with type 2 diabetes and chronic kidney disease.

  Recruiting Phase 2 Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences · Weifang, Shandong · NCT07496177

• Single-dose exenatide circular RNA in lipid nanoparticles for Chinese adults with type 2 diabetes

  This test gives a single injection of CR059 (exenatide circular RNA in a lipid nanoparticle) to see if it is safe and how it behaves in Chinese adults with type 2 diabetes.

  Recruiting Early Phase 1 The First Affiliated Hospital of Henan University of Science and Technology · Luoyang, Henan · NCT07347080

• Adding empagliflozin to alogliptin and metformin for type 2 diabetes

  This study tests whether adding empagliflozin to adults already taking alogliptin and metformin improves blood sugar control and is safe for people with type 2 diabetes who still have high blood sugar.

  Recruiting Phase 3 Celltrion · Seoul · NCT07093476

• Cofrogliptin every two weeks added to metformin and dapagliflozin versus daily linagliptin for type 2 diabetes

  This trial will test whether adding cofrogliptin every two weeks to metformin and dapagliflozin lowers HbA1c better than adding daily linagliptin in adults with type 2 diabetes whose blood sugar is not controlled on metformin plus an SGLT2 inhibitor.

  Recruiting at 2 sites Phase 4 Huazhong University of Science and Technology · Wuhan, Hubei and 1 other locations · NCT07019012

• Small-intestine calcium infusion to change gut function and blood sugar in men with type 2 diabetes

  This trial will test whether delivering calcium directly into the upper small intestine during short clinic visits changes gut function and blood sugar in men with type 2 diabetes.

  Recruiting University of Adelaide · Adelaide, South Australia · NCT06942195

• A system for preventing and controlling diabetic nephropathy

  This study is trying to create a system to better understand and manage diabetic nephropathy by collecting data on risk factors and symptoms from a large group of people with diabetes.

  Recruiting Chinese PLA General Hospital · Beijing, Beijing Municipality · NCT06843304

• Evaluation of GLP-1 receptor agonists for type 2 diabetes treatment

  This study is trying to find out which GLP-1 medications work best for adults with type 2 diabetes and how safe and effective they are in real life.

  Recruiting Qianfoshan Hospital · Jinan · NCT06686134

• Comparing Beinaglutide and Insulin for New Type 2 Diabetes Patients

  This study is testing whether a new treatment called Beinaglutide works better than insulin for adults who have just been diagnosed with type 2 diabetes.

  Recruiting at 16 sites Beijing Hospital · Beijing, Beijing Municipality and 15 other locations · NCT03987308

NIH-funded research (12)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Peer support to help older adults with type 2 diabetes in rural Appalachia

  Seeing if trained peer support can help older adults in rural Appalachian communities better manage their type 2 diabetes.

  NIH research University of Texas Med Br Galveston · Galveston, United States · NIH-11472036

• Continuous Glucose Monitoring versus Traditional Self-Monitoring for Non-Insulin Treated Adults with Type 2 Diabetes

  This grant tests whether wearing a CGM helps adults with type 2 diabetes who aren’t using insulin manage blood sugar better than traditional finger-stick checks.

  NIH research State University of New York at Buffalo · Amherst, United States · NIH-11448826

• Conditional cash transfers and basic needs support for adults with type 2 diabetes

  A funding-backed program will test whether helping low-income adults with type 2 diabetes meet basic needs improves their diabetes control and overall health.

  NIH research State University of New York at Buffalo · Amherst, United States · NIH-11424564

• TREAT-T2DM: AI-powered help to titrate diabetes treatments

  An AI tool called UpDoc Clinical Copilot helps manage diabetes medications remotely to improve blood sugar control for people with type 2 diabetes, especially in underserved communities.

  NIH research Updoc Ai · Los Altos, United States · NIH-11407615

• Predicting heart and blood vessel disease risk in type 2 diabetes using immune-cell computer tools

  This project uses new computer tools to read immune cell behavior and predict heart and blood vessel disease risk in people with type 2 diabetes.

  NIH research University of Connecticut Sch of Med/dnt · Farmington, United States · NIH-11258020

• Using cash incentives to improve health for African Americans with diabetes

  This study is looking at how giving cash rewards for healthy activities can help African Americans with type 2 diabetes living in city neighborhoods improve their health and manage stress from poverty and racism.

  NIH research State University of New York at Buffalo · Amherst, United States · NIH-11187675

• Helping older adults with type 2 diabetes in Appalachia through peer support.

  This study is all about helping older adults with type 2 diabetes in rural Appalachia by creating a friendly support program where they can share experiences and learn from each other to take better care of their health.

  NIH research University of Kentucky · Lexington, United States · NIH-11083604

• Assessing cardiovascular disease risk in patients with type 2 diabetes using advanced computational tools

  This study is looking at how type 2 diabetes can increase the risk of heart disease by examining the role of certain immune cells, and it aims to find better ways to predict and manage this risk for people with diabetes.

  NIH research University of Connecticut Sch of Med/dnt · Farmington, United States · NIH-10993204

• How type 2 diabetes affects brain health and dementia risk

  This study is looking at how not managing type 2 diabetes and prediabetes can affect brain health and memory in young adults aged 18 to 45, and it wants to find out if better diabetes management can help keep your mind sharp.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-10854563

• Exploring time-restricted eating as an alternative to calorie counting for managing type 2 diabetes

  This study is looking at whether eating only during certain hours of the day can help people with type 2 diabetes who are overweight, and who take metformin, to better manage their blood sugar and lose weight, compared to counting calories.

  NIH research University of Minnesota · Minneapolis, United States · NIH-10825524

• Helping Hispanic/Latino patients with diabetes manage their emotions and improve health.

  This study is all about helping Hispanic and Latino people with type 2 diabetes learn better ways to cope with their condition, using friendly techniques to improve their health and manage their diabetes more effectively.

  NIH research Baylor College of Medicine · Houston, United States · NIH-10695586

• Using low-dose pioglitazone to improve health outcomes in patients with type 2 diabetes and liver disease.

  This study is looking at how early check-ups and treatment can help people with type 2 diabetes who might also have a liver condition called NASH, and it will teach doctors about the benefits of spotting this issue early and using a medication called pioglitazone to help improve liver health.

  NIH research University of Florida · Gainesville, United States · NIH-10613936

Related topics

Quick answers

How many T2DM clinical trials are recruiting right now?

10, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 4 countries. The most sites are in China (7 trials), Australia (1 trial), United States (1 trial), South Korea (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 3, Phase 4: 1, Phase 3: 1, Early Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

Describe your situation →