Condition
Spastic Paraplegia clinical trials and research
As of November 12, 2026, Find a Trial lists 5 Spastic Paraplegia clinical trials that are recruiting, at sites in 4 countries (most in United States (2), Brazil (1), China (1)). By phase: Phase 4 (1), Phase 1/2 (1). Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 5Clinical trials
- 4Countries
Newest Spastic Paraplegia clinical trials
| Study | Phase | Where | Status | Registered |
|---|---|---|---|---|
| Palpatory vs ultrasound-guided botulinum toxin injections for spastic paraplegia | Phase 4 | Rio de Janeiro, Rio de Janeiro | Recruiting | Sep 3, 2026 |
| Measuring lower extremity activity in stroke patients | — | Gaziantep | Recruiting | Dec 5, 2023 |
| Observing the natural history of patients with HPDL mutations | — | San Diego, California | Recruiting | May 8, 2023 |
| Gene therapy for treating SPG50 in children | Phase 1/2 | Dallas, Texas | Recruiting | Aug 26, 2022 |
| Observational study on spastic paraplegia | — | Fuzhou | Recruiting | Jul 5, 2019 |
All recruiting trials (5)
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Palpatory vs ultrasound-guided botulinum toxin injections for spastic paraplegia
This study tests whether ultrasound-guided injections of botulinum toxin improve outcomes for adults with spastic paraplegia compared with the traditional palpation-guided method.
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Measuring lower extremity activity in stroke patients
This study is testing a new questionnaire to see how well stroke patients use their affected legs in daily activities to better understand their rehabilitation needs.
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Observing the natural history of patients with HPDL mutations
This study is trying to learn more about people with HPDL mutations and their related mitochondrial diseases by collecting health information and blood samples to see how these conditions change over time.
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Gene therapy for treating SPG50 in children
This study is testing a new gene therapy called MELPIDA to see if it can safely help children with Spastic Paraplegia Type 50 feel better and reduce their symptoms.
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Observational study on spastic paraplegia
This study is trying to learn more about how hereditary spastic paraplegia affects people over time so that doctors can better manage the condition.
Related topics
Quick answers
How many Spastic Paraplegia clinical trials are recruiting right now?
5, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.
Where are these trials running?
In 4 countries. The most sites are in United States (2 trials), Brazil (1 trial), China (1 trial), Turkey (Türkiye) (1 trial). Each study page lists its sites and which ones are recruiting.
What phases are they in?
Phase 4: 1, Phase 1/2: 1. Trials with no phase listed are usually device, behavioural or observational studies.
How do I join one?
Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.
Find the studies that fit you
A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.