Observational study on spastic paraplegia
Official title: A Registered Cohort Study on Spastic Paraplegia
Run by First Affiliated Hospital of Fujian Medical University · NCT04006418 · Data updated 2026-11-12
This study is trying to learn more about how hereditary spastic paraplegia affects people over time so that doctors can better manage the condition.
Quick facts
| Study type | Observational |
|---|---|
| Sex | All |
| Enrollment | 500 (estimated) |
| Sponsor | First Affiliated Hospital of Fujian Medical University Academic / other |
| Locations | 1 site (Fuzhou) |
| Status | Recruiting |
| Started | July 1, 2019 |
| Main results expected | December 2039 |
| Study ends | December 2049 |
| Registry record updated | January 19, 2022 |
| Trial ID | NCT04006418 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include patients with a clinical diagnosis of spastic paraplegia and unrelated healthy controls.
✕Probably not a fit
Patients who decline to participate or have serious interferences with participation may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study aims to explore the clinical spectrum and natural progression of Hereditary Spastic Paraplegias (HSP) and related disorders through a multicenter observational approach. It will assess various clinical, genetic, and epigenetic features of patients diagnosed with spastic paraplegia. The goal is to optimize clinical management by gathering comprehensive data on the condition's progression and characteristics.
Why it matters
Potential benefit: If successful, this study could enhance understanding and management of spastic paraplegia, leading to improved patient care.
How similar studies have gone: While this study focuses on a specific condition, similar observational studies have shown success in understanding the natural history of other neurological disorders.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients with the clinical diagnosis of spastic paraplegia * Clinical diagnosis of patients with spastic paraplegia * Unrelated healthy controls Exclusion Criteria: * Decline to participate. * There are serious interferences with individual participation and adherence to the research protocol, including but not limited to neurological, psychological, and/or medical conditions.
Where it's running
-
First Affiliated Hospital Fujian Medical University
Fuzhou, China Recruiting
Study contacts
- Study coordinator: Yi Lin, MD,PhD
- Email: wanjinchen75@fjmu.edu.cn
- Phone: +13615039153
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Palpatory vs ultrasound-guided botulinum toxin injections for spastic paraplegia
This study tests whether ultrasound-guided injections of botulinum toxin improve outcomes for adults with spastic paraplegia compared with the traditional palpation-guided method.
-
Measuring lower extremity activity in stroke patients
This study is testing a new questionnaire to see how well stroke patients use their affected legs in daily activities to better understand their rehabilitation needs.
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Observing the natural history of patients with HPDL mutations
This study is trying to learn more about people with HPDL mutations and their related mitochondrial diseases by collecting health information and blood samples to see how these conditions change over time.
-
Gene therapy for treating SPG50 in children
This study is testing a new gene therapy called MELPIDA to see if it can safely help children with Spastic Paraplegia Type 50 feel better and reduce their symptoms.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.