Condition

Secondary Progressive Multiple Sclerosis (SPMS) clinical trials and research

• 5Clinical trials
• 38Countries

Newest Secondary Progressive Multiple Sclerosis (SPMS) clinical trials

All recruiting trials (5)

• SUN-627 in non-active SPMS/PPMS: a Phase 2a test in adults

  This trial tests whether SUN-627 is safe and tolerable in adults with non-active primary or secondary progressive MS.

  Recruiting at 5 sites Phase 2 Sundance Biosciences, Inc. · Tampa, Florida and 6 other locations · NCT07840326

• TRX319 treatment for people with primary or secondary progressive multiple sclerosis

  This trial will test whether the experimental therapy TRX319, given with or without a short bendamustine pre-conditioning, is safe and can slow or improve disability in adults with primary or secondary progressive MS.

  Recruiting at 8 sites Phase 1/2 Tr1X, Inc. · La Jolla, California and 7 other locations · NCT07477639

• Remibrutinib for secondary progressive multiple sclerosis

  This trial will try remibrutinib versus placebo to see if it slows disability progression in adults with secondary progressive multiple sclerosis.

  Recruiting at 296 sites Phase 3 Novartis · Birmingham, Alabama and 295 other locations · NCT07225504

• Rituximab's effects on cognitive and hand functions in secondary progressive multiple sclerosis

  This study is testing if the medication rituximab can help improve thinking and hand skills in people with secondary progressive multiple sclerosis who have significant disabilities.

  Recruiting Phase 2 Cairo University · Giza, Giza Governorate · NCT06599307

• Imaging axonal damage and repair in multiple sclerosis

  This study is testing new MRI techniques to see how axons are damaged and repaired in people with multiple sclerosis over two years.

  Recruiting University Hospital, Basel, Switzerland · Basel · NCT05177523

Related topics

Quick answers

How many Secondary Progressive Multiple Sclerosis (SPMS) clinical trials are recruiting right now?

5, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 38 countries. The most sites are in United States (2 trials), Switzerland (2 trials), Egypt (1 trial), Argentina (1 trial), Australia (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 2, Phase 1/2: 1, Phase 3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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