Condition
Primary Progressive Multiple Sclerosis clinical trials and research
As of November 12, 2026, Find a Trial lists 4 Primary Progressive Multiple Sclerosis clinical trials that are recruiting, at sites in 3 countries (most in United States (2), United Kingdom (1), Germany (1)). By phase: Phase 1 (1), Phase 1/2 (1), Phase 2 (1). Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 4Clinical trials
- 3Countries
Newest Primary Progressive Multiple Sclerosis clinical trials
| Study | Phase | Where | Status | Registered |
|---|---|---|---|---|
| SUN-627 in non-active SPMS/PPMS: a Phase 2a test in adults | Phase 2 | Tampa, Florida and 6 other locations | Recruiting | Sep 25, 2026 |
| TRX319 treatment for people with primary or secondary progressive multiple sclerosis | Phase 1/2 | La Jolla, California and 7 other locations | Recruiting | Mar 17, 2026 |
| Sleep problems, fatigue, and thinking ability in people with MS | — | Düsseldorf and 1 other locations | Recruiting | Feb 23, 2026 |
| Investigating the safety of ixazomib for treating multiple sclerosis | Phase 1 | London, Greater London | Recruiting | Dec 21, 2018 |
All recruiting trials (4)
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SUN-627 in non-active SPMS/PPMS: a Phase 2a test in adults
This trial tests whether SUN-627 is safe and tolerable in adults with non-active primary or secondary progressive MS.
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TRX319 treatment for people with primary or secondary progressive multiple sclerosis
This trial will test whether the experimental therapy TRX319, given with or without a short bendamustine pre-conditioning, is safe and can slow or improve disability in adults with primary or secondary progressive MS.
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Sleep problems, fatigue, and thinking ability in people with MS
We will try to see if sleep problems explain why adults with MS feel very tired and have trouble thinking.
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Investigating the safety of ixazomib for treating multiple sclerosis
This study is testing if ixazomib can safely help people with multiple sclerosis by reducing certain markers in their spinal fluid.
Related topics
Quick answers
How many Primary Progressive Multiple Sclerosis clinical trials are recruiting right now?
4, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.
Where are these trials running?
In 3 countries. The most sites are in United States (2 trials), United Kingdom (1 trial), Germany (1 trial). Each study page lists its sites and which ones are recruiting.
What phases are they in?
Phase 1: 1, Phase 1/2: 1, Phase 2: 1. Trials with no phase listed are usually device, behavioural or observational studies.
How do I join one?
Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.
Find the studies that fit you
A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.