Condition

Multiple Sclerosis (MS) Primary Progressive clinical trials and research

• 7Clinical trials
• 1New in 30 days
• 21Countries

Newest Multiple Sclerosis (MS) Primary Progressive clinical trials

All recruiting trials (7)

• REAL-MS: A Look at Autologous Stem Cell Transplant vs High-Efficacy MS Therapies in Real-World Care

  This study tests how AHSCT compares to high-efficacy MS medicines in adults treated in routine clinical care.

  Recruiting Imperial College London · London and 2 other locations · NCT07899502

• Safety and dosing of S103 cells in progressive or refractory multiple sclerosis

  This trial tests S103 BCMA-CAR T cells in adults with progressive or refractory MS to see if it can be safely given and hint at benefit.

  Recruiting Phase 1 Xijing Hospital · Xi'an, Shaanxi · NCT07587125

• TRX319 treatment for people with primary or secondary progressive multiple sclerosis

  This trial will test whether the experimental therapy TRX319, given with or without a short bendamustine pre-conditioning, is safe and can slow or improve disability in adults with primary or secondary progressive MS.

  Recruiting at 8 sites Phase 1/2 Tr1X, Inc. · La Jolla, California and 7 other locations · NCT07477639

• Home-based functional balance program for people with multiple sclerosis

  This project will test whether a home-based functional balance program helps adults with multiple sclerosis improve physical and cognitive function and daily activities.

  Recruiting University of Illinois Chicago · Chicago, Illinois · NCT07355387

• Using short selfie videos to measure walking and speech changes in people with MS

  This project will test whether short selfie videos taken by people with MS can reliably show walking and speech changes similar to what clinicians see in person.

  Recruiting University of California, San Francisco · San Francisco, California · NCT07222618

• HBI0101 CAR-T for refractory B‑cell autoimmune rheumatic diseases

  This will test a single infusion of HBI0101 CAR‑T cells in adults with severe, treatment‑resistant B‑cell autoimmune diseases such as SLE, systemic sclerosis, idiopathic inflammatory myopathy, rheumatoid arthritis, or primary progressive MS.

  Recruiting Phase 1 Hadassah Medical Organization · Jerusalem · NCT07085676

• Orelabrutinib treatment for primary progressive multiple sclerosis

  This trial tests whether orelabrutinib, a brain-penetrant BTK inhibitor, can slow disability progression in adults with primary progressive MS.

  Recruiting at 86 sites Phase 3 Zenas BioPharma (USA), LLC · Pheonix, Arizona and 85 other locations · NCT07067463

Related topics

Quick answers

How many Multiple Sclerosis (MS) Primary Progressive clinical trials are recruiting right now?

7, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 21 countries. The most sites are in United States (4 trials), Australia (1 trial), Bulgaria (1 trial), Canada (1 trial), Croatia (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1: 2, Phase 3: 1, Phase 1/2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

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