Condition

Locally Recurrent Head and Neck Squamous Cell Carcinoma clinical trials and research

• 4Clinical trials
• 1Country

Newest Locally Recurrent Head and Neck Squamous Cell Carcinoma clinical trials

All recruiting trials (4)

• Adding chemotherapy or chemo-immunotherapy to standard salvage surgery for advanced head and neck cancer

  This trial tests whether giving chemotherapy alone or chemotherapy plus the immunotherapy cemiplimab before salvage surgery helps people with PD-L1–positive recurrent or persistent head and neck squamous cell carcinoma.

  Recruiting at 114 sites Phase 2 National Cancer Institute (NCI) · Tucson, Arizona and 114 other locations · NCT07195734

• Combination treatment for recurrent head and neck cancer

  This study is testing a new combination of medications and radiation to see if it helps people with tough-to-treat head and neck cancer feel better and live longer.

  Recruiting at 2 sites Phase 1 University of California, Davis · Sacramento, California and 1 other locations · NCT06211335

• Combining cabozantinib and nivolumab to treat advanced melanoma and head and neck cancer

  This study is testing a combination of two cancer drugs, cabozantinib and nivolumab, to see if they can help people with advanced melanoma or head and neck cancer while also looking at how to better match treatments to patients based on their tumor characteristics.

  Recruiting at 211 sites Phase 2 National Cancer Institute (NCI) · Phoenix, Arizona and 231 other locations · NCT05136196

• Combining immunotherapy and radiation for recurrent head and neck cancer

  This study is testing if combining a new immune treatment with radiation can help people with recurrent head and neck cancer feel better and live longer.

  Recruiting Phase 1 Ohio State University Comprehensive Cancer Center · Columbus, Ohio · NCT04754321

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Quick answers

How many Locally Recurrent Head and Neck Squamous Cell Carcinoma clinical trials are recruiting right now?

4, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

All of them have sites in United States. Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 2, Phase 1: 2. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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